It can activate downstream signaling pathways such as signal transducer and activator of transcription (STAT)1/3/5, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-魏B), mitogen-activated protein kinase (MAPK), and phosphoinositide 3-kinase (PI3K)-protein kinase B (AKT)-...
2021年3月21日，来自哈佛大学Laurie H. Glimcher团队在Nature Immonology 上发表题为Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias的文章。该研究发现在应激诱导性以及MDSs贫血中，IL22可以促进红系祖细胞凋亡，导致贫血；阻滞IL22途径可以逆转贫血。作者首先用造血细胞特异性单...
【5】Chiang H Y, Lu H H, Sudhakar J N, et al. IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence[J]. Nature communications, 2022, 13(1): 1-19. 【6】Gaudino S J, ...
【6】Gaudino S J, Beaupre M, Lin X, et al. IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity[J]. Mucosal immunology, 2021, 14(2): 389-401. 【7】Gaudino S J, Beaupre M, Lin X...
【6】Gaudino S J, Beaupre M, Lin X, et al. IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity[J]. Mucosalimmunology, 2021, 14(2): 389-401. ...
日前,德国汉堡-埃彭多夫大学医学中心和美国耶鲁大学医学院等合作,在Nature Communications杂志发表了题为:TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer 的研究论文。 该研究在体外实验中证实TGF-β信号传转导促进Th17细胞产生IL-22,还提供了第一个体内动物实验,证实TGF...
et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J. Exp. Med. 206, 1465–1472 (2009). 11. Monteleone, I. et al. Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointest- inal tract. ...
The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor.doi:10.1155/2015/912713Interleukin- (IL-) 22 signaling is protective in animal models of pneumonia and bacteremia by Klebsiella pneumoniae and mediates...
[5] Gaudino S.J., Beaupre M., Lin X., Joshi P., Rathi S., McLaughlin P.A., Kempen C., Mehta N., Eskiocak O., Yueh B., et al. IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella ...
et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J. Exp. Med. 206, 1465–1472 (2009). 27. Sugimoto, K. et al. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J. Clin. Invest. 118, 534–544 (2008). 28. ...