IL-2的信号通路 IL-2通过IL-2Rβ和γc的细胞质结构域的异源二聚发出信号，引起至少三个主要的信号通路被激活：磷酸肌醇3-激酶（PI3-K）/AKT、Ras-MAP激酶和JAK-STAT通路（主要是JAK1、JAK3；STAT5A和STAT5B；尽管STAT3和STAT1也可以被激活）（图1）。这三条信号通路共同介导细胞生长、存活、分化和免疫密切相...
5. Abul K. Abbas1, et al. Revisiting IL-2: Biology and therapeutic prospects. SCIENCE IMMUNOLOGY.6. Sarah H. Ross and Doreen A. Cantrell, Signaling and Function of Interleukin-2 in T Lymphocytes. Annu. Rev. Immunol.
【3】https://www.rndsystems.com/cn/pathways/il2-signaling-pathways
有研究表明，一些治疗也与信号途径的调节有关[29-30]，也与细胞的迁移、粘附及肿瘤血管生成等人类肿瘤的发生发展密切相关。另外，与其他细胞因子一样，IL-2信号传递同样受到细胞因子信号抑制物（Suppressor of cytokine signaling，SOCS） 家族蛋白的负调控。SOCS-3磷酸化可以抑制STAT-5磷酸化和T细胞增值，进而调控IL-...
另外,与其他细胞因子一样,IL-2信号传递同样受到细胞因子信号抑制物(Suppressor of cytokine signaling,SOCS) 家族蛋白的负调控。SOCS-3磷酸化可以抑制STAT-5磷酸化和T细胞增值,进而调控IL-2应答[25,31]。 四,IL-2的功能及生物学活性 IL-2是T细胞衍生的常见细胞因子。它在T细胞、B细胞、NK细胞、巨噬细胞和少突...
Consonni F, Favre C and Gambineri E (2021) IL-2 Signaling Axis Defects: How Many Faces? Front. Pediatr. 9:669298. Lidia Yshii et al, Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammati...
[3] Gaffen, S. L. (2001). SIGNALING DOMAINS OF THE INTERLEUKIN 2 RECEPTOR. Cytokine, 14(2), 63–77. [4] Barlic J, McDermott DH, Merrell MN, Gonzales J, Via LE, Murphy PM. (2004).Interleukin (IL)-15 and IL-2 reciprocally regulate expression of the chemokine receptor CX3CR1 thr...
Results We identified a lead candidate peptide, CMD178, which consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/sIL-2Rα signaling. Furthermore, production of cytokines (IL-2/interferon gamma [IFN-gamma]) and granules (perforin/granzyme B) was preserved in CD8~+ T ...
一、IL-2及炎症反应的相关概念 炎症反应 Inflammationisacompleximmuneresponsetoanarrayofcytokines,chemokines,andsignalingpathways.致炎因子作用于机体后，一方面引发组织细胞的损坏，使局部组织细胞显现变性、坏死；另一方面，诱导机体抗病机能增加，以益于清除致炎因子，使受损组织得到修复，从而使机体的内环境以及内环境和...
FOXP3+ regulatory T cells (Treg) are indispensable for immune homoeostasis and for the prevention of autoimmune diseases. Interleukin-2 (IL-2) signalling is critical in all aspects of Treg biology. Consequences of defective IL-2 signalling are insufficie