IL-2受体信号转导通路1. In order to study the mechanism of the interleukin-2 receptor signaling pathway in the breast cancer line and advance to reveal the primal anti-cancer effects of syk. 目的:本实验拟通过研究Syk与MDA-MB-231细胞株IL-2受体表达之间的相互影响,来探讨其相关信号转导途径,...
37]. The IL-2:IL-2R complex can signal via three major pathways, each activating different downstream transcriptional regulators [27,38,39]. Depending on the downstream signalling pathway, PI3K (PI3K-AKT-mTOR pathway
et al. TIM-3 suppresses anti-CD3/CD28-induced TCR activation and IL-2 expression through the NFAT signaling pathway. PLOS One 10, e0140694 (2015). Article PubMed PubMed Central CAS Google Scholar Yost, E. A., Hynes, T. R., Hartle, C. M., Ott, B. J. & Berlot, C. H. ...
Results We identified a lead candidate peptide, CMD178, which consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/sIL-2Rα signaling. Furthermore, production of cytokines (IL-2/interferon gamma [IFN-gamma]) and granules (perforin/granzyme B) was preserved in CD8~+ T ...
Research progress on the role and mechanisms of IL-33 ST2 signaling pathway in liver disease#br# BAI Yang, LEI Jia-hui ,GUAN Fei PDF (PC) 1038 摘要/Abstract 摘要:本文主要介绍了肝脏疾病中IL-33/ST2信号通路的作用及机制的研究现况。IL-33是机体主要的免疫调节因子,通过与多种免疫细胞(如Th2、Tre...
The IL-2R/JAK/STAT signaling pathway is instrumental in T and B lymphocyte development and functional maturation. Upon activation, this pathway orchestrates the nuclear translocation of specific transcription factors, thereby regulating the expression of multiple target genes, which notably include IL-2...
IL-2受体信号转导通路 1. In order to study the mechanism of the interleukin-2 receptor signaling pathway in the breast cancer line and advance to reveal the primal anti-cancer effects of syk. 目的:本实验拟通过研究Syk与MDA-MB-231细胞株IL-2受体表达之间的相互影响,来探讨其相关信号转导途径,从...
The unfolded protein response (UPR) is an intercompartmental signaling pathway between the endoplasmic reticulum (ER) and the nucleus. This signaling pathw... W Tirasophon - 《Tecnica Pecuaria En Mexico》 被引量: 664发表: 1999年 LPS rapidly traffics to and from the Golgi apparatus with the ...
原名:Triptolide analogue LLDT-8 ameliorates psoriasis-like dermatitis in BALB/c mice via suppressing the IL-36α signaling pathway 译名:雷公藤甲素类似物LLDT-8通过抑制IL-36α信号通路改善BALB/c小鼠银屑病样皮炎 期刊:Pharmacolog...
The decrease of CD8+ T cells in critical patients with COVID-19 pneumonia may be related to the IL-2 signaling pathway. The inhibition of IL-2/IL-2R gives rise to CD8+ T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia....