SignalingCellularImmuneResponse;CytokineSignaling Pathway Categories: TopFunctionsCellularDevelopment;CellularGrowthandProliferation;HematologicalSystemDevelopmentandFunction Diseases: Molecules:1-phosphatidyl-D-myo-inositol4,5-bisphosphate,Akt,cellcycleprogression,cellsurvival,Ck2,ELK1,ERK1/2,FOS,GRB2,IL2,IL2RA,IL2...
Provides evidence for the existence of a third interleukin-2 receptor-dependent signaling pathway. Sensitivity of the pathway to rapamycin; Induction of proto-oncogene bcl-2; Cooperation of c-Myc and Bcl-2 for the proliferation of cells independent of cytokines; Suppression of apoptosis by p56lck...
This reengagement depended on CXCR3 expression by CD8 T cells and was associated with increased STAT5 phosphorylation, indicating IL-2 signaling. Next, the researchers generated a mouse model to specifically deplete CD4 helpe...
Research progress on the role and mechanisms of IL-33 ST2 signaling pathway in liver disease#br# BAI Yang, LEI Jia-hui ,GUAN Fei PDF (PC) 1146 摘要/Abstract 摘要:本文主要介绍了肝脏疾病中IL-33/ST2信号通路的作用及机制的研究现况。IL-33是机体主要的免疫调节因子,通过与多种免疫细胞(如Th2、Tre...
[JAK]1/3-STAT pathway) are triggered. In T cells, and particularly Treg, phosphorylation of the IL-2Rβ chain and common γ chain by JAK1 and JAK3 and subsequent activation of STAT5 accounts for 90% of IL-2 signalling (Fig.2)[40,41]. In Treg, the PI3K-AKT-mTOR pathway is ...
et al. TIM-3 suppresses anti-CD3/CD28-induced TCR activation and IL-2 expression through the NFAT signaling pathway. PLOS One 10, e0140694 (2015). Article PubMed PubMed Central CAS Google Scholar Yost, E. A., Hynes, T. R., Hartle, C. M., Ott, B. J. & Berlot, C. H. ...
10. Li Y, Yuan L, Jiang S, Liu S, Xia L, Shen H, et al. Interleukin-35 stimulates tumor necrosis factor-α activated osteoblasts differentiation through Wnt/β-catenin signaling pathway in rheumatoid arthritis. Int ...
IL-17 signaling pathway The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defined T helper 17 (TH17) cell subset, has important roles in protectin...
（4）Cavalcante LB, Tanaka MH, Pires JR, et al. (2012) Expression of the Interleukin-10 Signaling Pathway Genes in Individuals With Down Syndrome and Periodontitis. J Periodontol 83(7):926-35.（5）José M. Rojas , Miguel Avia , Verónica Martín , et al. （2017）IL-10: A ...
B. T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol. Cell. Biol. 7, 4472–4481 (1987). CAS PubMed PubMed Central Google Scholar Granucci, F. et al. Inducible IL-2 production by dendritic cells revealed by global ...