IL-1家族细胞因子通过与受体亚基结合激活细胞内信号通路,如IL-1RI/IL-1R1、IL-18Rα/IL-1R5、IL-1Rrp2/IL-1R6或ST2/IL-1R4,然后募集一个辅助受体来形成活性受体复合物。由IL-1α、IL-1β、IL-18、IL-33、IL-36α、IL-36β或IL-36γ触发的信号级联激活MAPK和NF-κB,导致促炎因子、趋化因子和炎症...
作者将通过ATAC-seq得到的peaks与HeLa衍生的KB细胞(IL-1刺激后)生成的RelAChIP-seq数据集进行了比较(Allis et al., 2016),结果显示刺激后明显更容易接近的区域中有50%包含至少一个相关的RelA结合的ChIP-seq峰,比例明显增加,表明这些区域在IL-1刺激下对RelA有显著的亲和力(图1g)。 图1 ATAC-seq识别出IL-1刺激...
从机制上讲,过度的肺动脉平滑肌增殖与炎症小体NLRP3和活性IL-1β密切相关。Caspase-8通过调节NLRP3/IL-1β信号通路促进肺血管周围炎性细胞浸润和肺动脉平滑肌细胞增殖。 结论:巨噬细胞在促进PAH肺血管重塑中发挥重要作用,而巨噬细胞通过c...
The IL-i receptor signaling pathway Interleukin-1 (IL-i) exerts pleiotropic effects on a variety of tissues through binding to its receptor. Two distinct types of receptors for IL-i have been characterized in mouse and human. Most of the IL-i signal has been shown to be tr... K Kuno,...
We aim to determine the dose- and time-dependent effects of IL-1beta and morphine on MOR expression in SK-N-SH cells and elucidate the signaling pathway responsible for this regulation of MOR using quantitative real-time-PCR (qRT-PCR) and immunocytochemistry (ICC). A time-dependent IL-1...
5.Hu, X., li, J., Fu, M., Zhao, X. and Wang, W. (2021). The JAK/STAT signaling pathway: from bench to clinic. Signal Transduction and Targeted Therapy, 6(1). doi:https://doi.org/10.1038/s41392-021-00791-1. 发布于 2023-03-04 09:28...
种植体周围炎/白细胞介素1β/肿瘤坏死因子α/RANKL/OPG/NF-κB受体活化因子配体; Key words Peri-implantitis/Interleukin-1β/Tumor necrosis factor-α/Receptor activator for nuclear factor-κB ligand;/Osteoprotegerin/Nuclear transcription factor kappaB signaling pathways ...
3.Cavalcante LB, Tanaka MH, Pires JR, et al. (2012) Expression of the Interleukin-10 Signaling Pathway Genes in Individuals With Down Syndrome and Periodontitis. J Periodontol 83(7):926-35. 4.José M. Rojas , Miguel Avia , Verónica Martín , et al...
5.Hu, X., li, J., Fu, M., Zhao, X. and Wang, W. (2021). The JAK/STAT signaling pathway: from bench to clinic. Signal Transduction and Targeted Therapy, 6(1). doi:https://doi.org/10.1038/s41392-021-00791-1. ...
75 Role of the IL1 signaling pathway in the development of type 2 airway inflammation in juvenile Scnn1b-Tg miceGenetic background has no effect on early airway inflammation in neonatal βENaC-Tg mice. A, B) Levels of KC (A) and TNF-α (B) in lung homogenates from 3-day-old ...