Recent work has illuminated many important negative regulators of these signaling pathways, which may be important for preventing inflammatory disease.References (0) Cited by (3) Effects of acupuncture on microglial polarization and the TLR4/TRIF/MyD88 pathway in a rat model of traumatic brain ...
(2003). The Expanding Interleukin-1 Family and Its Receptors: Do Alternative IL-1 Receptor/Signaling Pathways Exist in the Brain? Molecular Neurobiology, 27(3), 239–248.[11]Ron N. Apte and Elena Voronov, Immunotherapeutic approaches of IL-1 neutralization in the, J Leukoc Biol published ...
The expanding interleukin-1 family and its receptors: do alternative IL-1 receptor/signaling pathways exist in the brain? Mol Neurobiol, 2003, 2 7 (3): 239~248Boutin H, Kimber I, Rothwell NJ, Pinteaux E. The expanding interleukin-1 family and its receptors: do alternative IL-1 receptor...
Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30, 576–587 (2009). This paper currently provides the broadest study of the involvement of IL-1 in T H 17 cell development. Article CAS PubMed PubMed Central Google Scholar Kryczek, I. et al. ...
signaling complex [58]. IL-1R1, along with IL-1RAcP as a co-receptor [57] and TIR domains, cause the activation of NF-κB, p38, JNKs, and mitogen-activated protein kinases (MAPKs) pathways [55]. IL-1R2 (CD121b) is another receptor for IL-1 cytokines. Although IL-1R2 binds ...
Interleukin (IL)-1R3 is the co-receptor in three signaling pathways that involve six cytokines of the IL-1 family (IL-1α, IL-1β, IL-33, IL-36α, IL-36β and IL-36γ). In many diseases, multiple cytokines contribute to disease pathogenesis. For example, in asthma, both IL-33 ...
Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction T1/ST2 is a member of the interleukin (IL)-1 receptor superfamily, possessing three immunoglobulin domains extracellularly and a Toll/IL1R...
The signaling pathways that modulate IL-1β expression in human keratinocytes have not been well defined. We have previously shown that TCDD-stimulated AhR-dependent IL-1β expression in human keratinocytes is due to posttranscriptional regulation involving mRNA stabilization. Since TCDD activates a var...
为了解决肿瘤基质内的这种免疫抑制,人们对免疫应答细胞工程化以进一步 表达一种或多种促炎细胞因子(如白细胞介素(IL)‑12和/或IL‑1超家族成员)感兴趣。 [0002] IL‑1超家族由11名成员组成。见Baker等人“IL‑1 family members in cancer; two sides to every story,”Front.Immunol.10:Article 1197(...
University of Michigan Medical School, Ann Arbor, MI, USA Evidence in animal models suggests IL-1 family cytokines interact with central endogenous opioid neurotransmitter systems, inducing or perpetuating pathological states such as persistent pain syndromes, depression, substance use disorders, and their...