Interleukin-1 beta (IL-1β) is an important regulator of the thyroid cell function. This cytokine has been largely described to trigger an important biological signaling cascade: the sphingomyelin/ceramide pathway. In this report, we show that IL-1β induces the transient activation of a ...
In order to elucidate the signal transduction pathways responsible for IL-1beta regulation of MOR a qRT-PCR array was completed, revealing a significant role of the human p38 MAPK pathway. Next using signaling inhibitors, SN50 (NF-κB), PD98059 (MEK1/2) and SB203580 (p38 MAPK), using ...
Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is instead secreted alongside caspase-1 via an alternate and incomple...
2002. IL-1beta activates C/EBP-beta and delta in human enterocytes through a mitogen-activated protein kinase signaling pathway. Int J Biochem Cell Biol... ES Hungness,TA Pritts,GJ Luo,... - 《International Journal of Biochemistry & Cell Biology》 被引量: 48发表: 2002年 Proteasome Inhibito...
Signaling pathway of interest was identified based on high throughput sequencing results, in which the differentially expressed genes were verified by qRT-PCR, Western Blot, and immunofluorescence staining. Results 1 In vivo experiment: compared with the control group, the pulmonary collagen ...
signaling pathway were predicted to be targeted by at least one microRNA enriched in ADEV-IL-1β or ADEV-TNFα, and two key genes in this pathway (NTRK3/TRKC and BCl2) were predicted to be targeted by both miR-125a-5p and miR-16-5p that were enriched in ADEV-IL-1β and A...
A signaling pathway by which calcium influx regulates the expression of the major activity-dependent transcript of BDNF in cortical neurons has been elucid... PB Shieh,SC Hu,K Bobb,... - 《Neuron》 被引量: 1478发表: 1998年 Interleukin-1 immunoreactive innervation of the human hypothalamus Int...
Although metformin reportedly inhibits mature IL-1β secretion via NLRP3 inflammasome in macrophages of T2DM patients, it remains unclear whether it affects skin inflammation in psoriasis. To test this, we analysed normal human epidermal keratinocytes (NHEKs), a major skin component, stimulated with ...
Opposing to that, human monocytes engage an alternative NLRP3 inflammasome pathway in response to LPS that proceeds in the absence of signal 2 activation and enables IL-1β secretion without pyroptosis. This specifically relies on Caspase-8 to propagate signaling to NLRP3, leading to inflammasome ...
IL-1α is an essential cytokine that contributes to inflammatory responses and is implicated in various forms of pathogenesis and cancer. Here we report a naphthyl modified DNA aptamer that specifically binds IL-1α and inhibits its signaling pathway. By solving the crystal structure of the IL-1...