结果与对照组比较,过表达组、空白组、模型组P2X7R mRNA和蛋白相对表达量升高,细胞上清液IL-1β、TNF-α水平升高,细胞NLRP3蛋白相对表达量升高(P均<0.05);与模型组、空白组比较,过表达组P2X7R mRNA、蛋白相对表达量升高,细胞上清液I...
Our findings demonstrate that pro-IL-1 beta is a substrate of ICE relevant to cell death, and depending on the temporal cellular commitment to apoptosis, mature IL-1 beta may function as a positive or negative mediator of cell death.
英文名称 :IL-1 Beta 中文名称 :白介素1β/IL-1β抗体 别名:Catabolin; H1; IL-1β; Hematopoietin 1; IFN beta inducing factor; IL 1; IL 1 beta; IL 1B; IL1B; IL1F2; Interleukin 1 beta; Interleukin 1 beta precursor; LAF; OAF; Osteoclast activating factor; Preinterleukin beta; Pro...
IL-36 beta可激活 M2 样巨噬细胞和朗格汉斯细胞;在骨髓树突状细胞中,IL-36 刺激引起促炎性细胞因子(如 IL-1β、IL-6、IL-12、IL-23 和 TNF)的产生增加,这些细胞因子可能会驱动先天性和适应性免疫反应。IL-36R 主要在初始 CD4 + T 细胞上表达,促进向Th1,Th17分化,并促进其增殖和炎症细胞因子产生。此外...
Catabolin,Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP),Leukocyte Endogenous Mediator (LEM),Mononuclear Cell Factor (MCF),IL1B,IL-1BETA,IL1F2,IL-1β 蛋白序列(Protein Sequence) DNA 序列编码人 IL-1β(GenBank: AAA72849.1)表达带有 His 标签在 C 末端 ...
NCT02443155 A Clinical Proof-of-principle Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of NNC0114-0006 and Liraglutide on Preservation of Beta-cell Function。 不过只是轻微的改善疾病,可能原因是CD4+T产生更多的IL-...
进一步研究发现,IL18通过NCC调控β细胞发育转录因子PDX1的表达;在人的胰岛组织中,NCC抑制剂氢氯噻嗪可以抑制IL18诱导的PDX1表达和胰岛素分泌。IL18 与胰高血糖素样肽GLP1相互作用,通过NCC和GLP1受体GLP1r共同作用于β细胞,驱动β细胞发育和胰岛素分泌。此外,IL18也可以通过腺泡细胞上的IL18r抑制糖尿病小鼠胰腺中巨...
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function and IL-1β activation17, and A20 haploinsufficiency or deletion can drive damaging hyperinflammation in humans and mice18,19,20,21. Nevertheless, a detailed mechanistic analysis of pro-IL-1β post-translational modification is required to determine how inflammatory responses may be fine-...
产品名称:Recombinant Human Interleukin-1 beta(rHuIL-1β) 产品价格: 货号 规格 价格 101-01B 2μg 600 101-01B 10μg 1500 101-01B 100μg 7170 101-01B 250μg 12900 101-01B 500μg 16770 101-01B 1mg 22930 技术参数: Synonyms Catabolin, Leukocyte Endogenous Mediator, LEM, Lymphocyte-activating...