A New Function for an Old Enzyme: The Role of DNase I in Apoptosis Programmed cell death or apoptosis (Greek for the falling of the leafs in autumn) is an event by which cells are deliberately eliminated (recently reviewed... HG Mannherz,MC Peitsch,S Zanotti,... - Springer Berlin Heidel...
Taken together, these data contribute to underline an emerging physiological concept postulating that a same molecule may have opposite effects as a function of the cellular context. 展开 关键词: Cytokines Neurotrophins PGE2 Astrocytes Neurons Hypothalamus Prostaglandin receptors ...
IL-1β 是 IL-1 家族中的明星因子。IL-1β 主要由由单核细胞、巨噬细胞、树突状细胞等先天免疫系统的核心成员生成并释放:在模式识别受体 (PRR) 被病原体相关分子模式 (PAMP) 或损伤相关分子模式 (DAMP) 激活时,IL-1β 以无活性的前体形式 (pro-IL-1β) 产生,随后经 caspase-1 切割为活性形态,进而被...
介绍了ＩＬ－１β的产生和功能；在ＡＬＤ中通过对肝实质细胞与非实质细胞的作用推进肝脂肪变性和炎症，通过调控肝星状细胞的增殖来加速肝纤维化，指出通过干扰ＩＬ－１β的途径可能成为未来治疗ＡＬＤ的策略之一。关键词：肝疾病，酒精性；脂肪肝，酒精性；白细胞介素１β中图分类号：Ｒ５７５ 文献标志码：...
Regulatory T (Treg) cells play an essential role in immune homeostasis by controlling the function of various immune effector cells, including RAR-related ... A Tsun,Z Chen,B Li - 《Protein & Cell》 被引量: 16发表: 2011年 低氧诱导因子-1α信号活化在川崎病患儿Th17/调节性T淋巴细胞失衡中的...
(0.01),但与正常组无明显差异(P> 0.05).非激素组血浆TNF一,IL—lB水平在各时间点均明显高于正常组(0.01).结论糖皮质激素对降低颅脑损伤患者血浆 1'NF,IL.1B水平具有明显的延迟性,使损伤早期因TNF一6【,IL.1B显着升高引起的有害作用未能消除,至恢复期又使TNF—Of., IL.1B明显降低,其神经保护作用不能...
12、inflammatory function by IL-10 implications for systemic lupus erythematosus pathogenesisJ.J Immunol ,2004, 172 ( 10 ): 6476-6481.5 Sun KH, Yu CL, Tang S,I etal.Monoclonal anti-double-stranded DNA autoantibody stimulates the expression and release of IL-1 beta , IL-6, IL-8, IL-10 ...
TNF-alpha and IL-1 alpha inhibit both pyruvate dehydrogenase activity and mitochondrial function in cardiomyocytes: evidence for primary impairment of ... R Zell,P Geck,K Werdan,... 被引量: 0发表: 1997年 Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to nor...
function and IL-1β activation17, and A20 haploinsufficiency or deletion can drive damaging hyperinflammation in humans and mice18,19,20,21. Nevertheless, a detailed mechanistic analysis of pro-IL-1β post-translational modification is required to determine how inflammatory responses may be fine-...
Catabolin,Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP),Leukocyte Endogenous Mediator (LEM),Mononuclear Cell Factor (MCF),IL1B,IL-1BETA,IL1F2,IL-1β 蛋白序列(Protein Sequence) DNA 序列编码人 IL-1β(GenBank: AAA72849.1)表达带有 His 标签在 C 末端 ...