A New Function for an Old Enzyme: The Role of DNase I in Apoptosis Programmed cell death or apoptosis (Greek for the falling of the leafs in autumn) is an event by which cells are deliberately eliminated (recently reviewed... HG Mannherz,MC Peitsch,S Zanotti,... - 《Curr Top Microbiol...
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Psychopharmacologic agents can differentially effect cytokine production, which suggests that therapeutic function of neuroleptics may involve immunomodulation. The present study was carried out to examine: (i) serum concentrations of interleukin (IL)-1beta, soluble interleukin-2 receptor (sIL-2R), IL...
IL-36 beta可激活 M2 样巨噬细胞和朗格汉斯细胞;在骨髓树突状细胞中,IL-36 刺激引起促炎性细胞因子(如 IL-1β、IL-6、IL-12、IL-23 和TNF)的产生增加,这些细胞因子可能会驱动先天性和适应性免疫反应。IL-36R 主要在初始 CD4 + T 细胞上表达,促进向Th1,Th17分化,并促进其增殖和炎症细胞因子产生。此外,...
function and IL-1β activation17, and A20 haploinsufficiency or deletion can drive damaging hyperinflammation in humans and mice18,19,20,21. Nevertheless, a detailed mechanistic analysis of pro-IL-1β post-translational modification is required to determine how inflammatory responses may be fine-...
We have examined the lipopolysaccharide (LPS) induced release of interleukin 1β (IL-1β), IL-6, IL-8 and tumour necrosis factor alpha (TNF-α), in EDTA or heparin anticoagulated whole blood, from persons with high or low levels of high density lipoprotein (HDL), incubated at 37°C fo...
Astrocytes are known to be critical regulators of neuronal function. However, relatively few mediators of astrocyte to neuron communication have been identified. Recent advancements in the biology of extracellular vesicles have begun to implicate astrocy
IL-1α, like IL-33 and IL-37, is a ‘dual-function’ cytokine binding to chromatin as well as to its cell surface receptor. Upon a signal initiating apoptosis, cytosolic IL-1α moves to the nucleus, remains tightly bound to chromatin, and is unavailable for initiating inflammation. In co...
英文名称 :IL-1 Beta 中文名称 :白介素1β/IL-1β抗体 别名:Catabolin; H1; IL-1β; Hematopoietin 1; IFN beta inducing factor; IL 1; IL 1 beta; IL 1B; IL1B; IL1F2; Interleukin 1 beta; Interleukin 1 beta precursor; LAF; OAF; Osteoclast activating factor; Preinterleukin beta; Pro...
Human IL-1 beta /IL-1F2 Antibody Summary Species Reactivity Human Specificity Detects human IL-1 beta /IL-1F2 in sandwich ELISAs and Western blots. In sandwich ELISAs, less than 4% cross-reactivity with recombinant rat (rr) IL‑1 beta and less than 0.1% with recombinant porcine (rp...