J Biol Chem 273, 17846-17851.Cheneval D, Ramage P, Kastelic T, Szelestenyi T, Niggli H, Hemmig R, Bachmann M, and MacKenzie A. Increased mature interleukin-1beta (IL-1beta) secretion from THP-1 cells induced by nigericin is a result of activation of p45 IL-1beta- converting enzyme...
Guia S等研究发现在IL12RB1突变导致IL-12Rbeta1完全缺乏的患者中,NK细胞亚群明显减少,特别是对于IFN-γ的产生;从IL-12p40完全缺失的患者中也获得了类似的数据。此外,IL-12Rbeta1-和IL-12p40缺陷患者表达CD56的效应记忆T细胞亚...
Fig4:Recombinant Human IL-18 stimulates proliferation of KG-1 ►重组人IL-21蛋白 Fig5:Recombinant human IL-21 protein stimulates secretion of IFN- γ by NK-92 二、NK培养试剂盒套装 ►NK总细胞扩增变化 ►NK细胞活率变化 ►NK细胞扩增比例 参考文献: Soiffer RJ, Murray C, Shapiro C, Colli...
Although metformin reportedly inhibits mature IL-1β secretion via NLRP3 inflammasome in macrophages of T2DM patients, it remains unclear whether it affects skin inflammation in psoriasis. To test this, we analysed normal human epidermal keratinocytes (NHEKs), a major skin component, stimulated with ...
Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions.IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. These cytokines play important roles ...
a similarly high ratio has been reported at the mRNA level in corneal wounds of streptozotocin-induced diabetic mice9. Further supporting thatLeprdb/dbmice have higher IL-1R1 signalling levels, we found that IL-1β secretion is enhanced inLeprdb/dbmacrophages derived from bone marrow. Our reasoni...
The production of IL-2 and the mitogen response were significantly lower in PD patients, whereas the secretion of IL-1β, IL-6 and TNF-α were significantly enhanced. To evaluate the role of levodopa in creating immunological alterations, PBMC of patients and controls were incubated with ...
Similarly, the expression of F-actin was increased at low concentrations and decreased at high concentrations.Conclusions: IL-1 beta has a critical role in regulating hippocampal neuron viability by stimulating F-actin expression. These data suggest that IL-1 beta secretion at low doses is ...
Fig. 4: Arginase-2 influences complex-II activity and regulates IL-1β secretion. a–e XFe96 based comparison of complex I and/or complex II specific OCR in untreated (CTL) BMDM or stimulated cells (with LPS or LPS + IL-10 for 24 h). Data plotted as oxygen consumption rate ...
induce the NO secreted by RAW264.7 cells with a certain dose dependency,and the NO secretion volume was obviously increased after LPS(1 μg/mL)or TNF-α(10 ng/mL),and IL-1β(10 ng/mL)stimulation for 6～48 h could obviously induce the secretion of NO with a certain dose dependency. ...