secretion of IL-1b is regulated by zincPannexin-1-dependent caspase-1 activation andEt AlDoi EurJ. ImmunolDavid BroughPablo PelegrinNancy J. Rothwell
Pharmacological blockade of the IL-1 receptor inCPinfected wild-type mice phenocopies Caspase-1-deficient mice, and administration of recombinant IL-1β rescuesCPinfected Caspase-1/mice from mortality, indicating that IL-1β secretion is crucial for host immune defense againstCPlung infection.In ...
ARTICLES Neutrophilic NLRP3 inflammasome-dependent IL-1b secretion regulates the gdT17 cell response in respiratory bacterial infections M Hassane1,2, D Demon3,4, D Soulard1, J Fontaine1, LE Keller5, EC Patin1, R Porte1, I Prinz6, B Ryffel7, A Kadioglu8, J-W Veening5, J-C ...
Polyhydroxylated Metallofullerenols Stimulate IL‐1β Secretion of Macrophage through TLRs/MyD88/NF‐κB Pathway and NLRP3 Inflammasome Activation[J] . Zhiyun Chen,Ying Liu,Baoyun Sun,Han Li,Jinquan Dong,Lijuan Zhang,Liming Wang,Peng Wang,Yuliang Zhao,Chunying Chen.Small . 2014 (12)...
Processing and secretion of IL-1β requires conversion of procaspase-1 to active caspase-1, which depends on theinflammasome, in particularNLRP3(Hoffman et al., 2001), also calledcryopyrin.Neutrophilsrelease huge amounts of bioactive IL-1β in response to inflammasome activators, including ATP,ni...
The secretion of NGF, PGF2α, and PGE2 in the tissue culture medium was analyzed through ELISA. 2. Results 2.1. IL1B and IL1R1 Male Tissue Gene Expression The 260/280 RNA ratio was 1.95, while the 260/230 ratio was 2.1, indicating the high purity of RNA preparation in each sample. ...
Short Term Metformin Intervention Inhibits IL-6 and IL-1β Secretion and Prevents Acute Respiratory Distress Syndrome-Implications for COVID-19 来自 SSRN 喜欢 0 阅读量: 23 作者: H Xian,Y Liu,A Rundberg Nilsson,TR Crother,RA Porrit,GR Aleman-Muench,G Lewis,M Luevanos,D Trudler,SA Lipton ...
Inflammasome-Mediated Secretion of IL-1尾 in Human Monocytes through TLR2 Activation; Modulation by Dietary Fatty Acids Many studies have shown that TLR4- and TLR2-defici RG Snodgrass,S Huang,IW Choi,... 被引量: 112发表: 2013年 Inflammasome-mediated secretion of IL-1bin human monocytes throug...
While loss of PTPN22 resultsin decreased NLRP3-mediated IL1B secretion, presence of avariant in the gene encoding PTPN22 promotes inflammasomeactivity.9 尽管缺乏PTPN22会导致NLRP3介导的IL1B分泌减少,突变体在编码PTPN22的基因中促进炎性小体的活性。 This variant has been associated with increased risk ...
[2]. Macrophages are crucial immunological regulators and mediators of inflammation; therefore, the secretion of macrophage-derived inflammatory cytokines, such as interleukin (IL)-1 and IL-6, is known to induce kidney damage and inflammation [3]. Inflammatory macrophages are activated and ...