The secretion of IL-1b is essential for initiating a cascade of events that are aimed at reestablishing homeostasis. Prolonged or inappropriatesecretion of IL-1b, however, is associated directly or indirectly with a number of pathologicalconditions including leukemia, atherosclerosis, rheumatoid ...
[2]. Karina Zitta, et al. Interleukin-1beta regulates cell proliferation and activity of extracellular matrix remodelling enzymes in cultured primary pig heart cells. Biochem Biophys Res Commun. 2010 Sep 3;399(4):542-7. [3]. Kenichi Shimada, et al. Caspase-1 dependent IL-1β secretion is...
[2]. Karina Zitta, et al. Interleukin-1beta regulates cell proliferation and activity of extracellular matrix remodelling enzymes in cultured primary pig heart cells. Biochem Biophys Res Commun. 2010 Sep 3;399(4):542-7. [3]. Kenichi Shimada, et al. Caspase-1 dependent IL-1β secretion is...
[2]. Karina Zitta, et al. Interleukin-1beta regulates cell proliferation and activity of extracellular matrix remodelling enzymes in cultured primary pig heart cells. Biochem Biophys Res Commun. 2010 Sep 3;399(4):542-7. [3]. Kenichi Shimada, et al. Caspase-1 dependent IL-1β secretion is...
ARTICLES Neutrophilic NLRP3 inflammasome-dependent IL-1b secretion regulates the gdT17 cell response in respiratory bacterial infections M Hassane1,2, D Demon3,4, D Soulard1, J Fontaine1, LE Keller5, EC Patin1, R Porte1, I Prinz6, B Ryffel7, A Kadioglu8, J-W Veening5, J-C ...
Polyhydroxylated Metallofullerenols Stimulate IL‐1β Secretion of Macrophage through TLRs/MyD88/NF‐κB Pathway and NLRP3 Inflammasome Activation[J] . Zhiyun Chen,Ying Liu,Baoyun Sun,Han Li,Jinquan Dong,Lijuan Zhang,Liming Wang,Peng Wang,Yuliang Zhao,Chunying Chen.Small . 2014 (12)...
Pharmacological blockade of the IL-1 receptor inCPinfected wild-type mice phenocopies Caspase-1-deficient mice, and administration of recombinant IL-1β rescuesCPinfected Caspase-1/mice from mortality, indicating that IL-1β secretion is crucial for host immune defense againstCPlung infection.In ...
In Caucasian populations from Scotland and Poland,H. pylori-infected patients with lowacid secretionexhibit higher frequency of the haplotypeIL1B–31T/1L-1B–511T and/orhomozygosityforIL1RN∗2.140However, it has been noted that near-completelinkage disequilibriumexists between polymorphisms at −...
While loss of PTPN22 resultsin decreased NLRP3-mediated IL1B secretion, presence of avariant in the gene encoding PTPN22 promotes inflammasomeactivity.9 尽管缺乏PTPN22会导致NLRP3介导的IL1B分泌减少,突变体在编码PTPN22的基因中促进炎性小体的活性。 This variant has been associated with increased risk ...
Biological activity Background information IL-1β is mainly secreted by monocytes and macrophages. IL-1β secretion has also been reported for a variety of other cells, including B cells, NK cells, dendritic cells, astrocytes, and microglial cells. IL-1β acts also on nonimmune system cells ...