secretion of IL-1b is regulated by zincPannexin-1-dependent caspase-1 activation andEt AlDoi EurJ. ImmunolDavid BroughPablo PelegrinNancy J. Rothwell
Pharmacological blockade of the IL-1 receptor inCPinfected wild-type mice phenocopies Caspase-1-deficient mice, and administration of recombinant IL-1β rescuesCPinfected Caspase-1/mice from mortality, indicating that IL-1β secretion is crucial for host immune defense againstCPlung infection.In ...
Nikolakopoulou AM, Dutta R, Chen Z, Miller RH, Trapp BDActivated microglia enhance neurogenesis via trypsinogen secretion.Proc Natl Acad Sci U S A. 2013 May 21;110(21):8714-9. doi: 10.1073/pnas.1218856110. Epub 2013 May 6. 作为中外知名的单克隆抗体和蛋白生产商,Abnova的金牌品质使其成为全...
Processing and secretion of IL-1β requires conversion of procaspase-1 to active caspase-1, which depends on theinflammasome, in particularNLRP3(Hoffman et al., 2001), also calledcryopyrin.Neutrophilsrelease huge amounts of bioactive IL-1β in response to inflammasome activators, including ATP,ni...
(100mg/ml) was given to increas the releasing of TNF-α and IL-1β induced by PMΦ.The concentration of TNF-α and IL-1β in supernatant was determined by ELISA.Results: The LPS induced secretion of TNF-α and IL-1β in PMΦ could be significantly inhibited by Rhizoma Paridis total...
IL-1beta or TNF-alpha alone induced increased secretion of type IV collagen, laminin-1, and nidogen-1/entactin, all of which contributed to this upregulation. In contrast, while SV40-T2 cells cultured with a fibroblasts-embedded type I collagen gel were able to form a continuous basement ...
ELISA analysis further confirmed TFDG treatment significantly decreased the secretion of inflammatory factors. Western blot results showed that TFDG treatment significantly inhibited the inflammation-related enzyme COX-2 expression. Taken together, these results indicate that TFDG has a preventive effect on...
While loss of PTPN22 resultsin decreased NLRP3-mediated IL1B secretion, presence of avariant in the gene encoding PTPN22 promotes inflammasomeactivity.9 尽管缺乏PTPN22会导致NLRP3介导的IL1B分泌减少,突变体在编码PTPN22的基因中促进炎性小体的活性。 This variant has been associated with increased risk ...
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We further demonstrated that CSFV viroporin p7 protein induced IL-1β secretion which could be inhibited by the ion channel blocker amantadine and also discovered that p7 protein was a short-lived protein degraded by the proteasome. Together, our observations provided an insight into the mechanism ...