第一, IL-1α通常与其所产生的细胞质膜关系较大,因此只能局部起作用,而IL-1β可以全身分泌并循环作用;第二, IL-1α表达比较普遍,主要在上皮细胞、角化细胞和内皮细胞中表达,也可以在骨髓细胞表达, IL-1β主要由单核细胞和巨噬细胞产生;第三, IL-1α在不同部位被各种蛋白酶(包括钙蛋白酶,颗粒酶B和炎性...
因此,作者认为,这项研究促进了人们更好地了解青光眼发病机制,并指出可以针对原发性疾病病变研究新的治疗策略,发现新的治疗方法。 原文出处: Oliveira, M.B., et al.,Association between IL1A and IL1B polymorphisms and prima...
◆ IL-1α作为一种完整的膜蛋白发挥作用,而IL-1β不存在于细胞膜上; ◆ IL-1α在核内是活跃的,而IL-1β不存在于细胞核中; ◆ IL-1α在疾病状态的体液循环中很少报告,而IL-1β在健康和疾病的体液循环中都存在。 02 IL-1α与IL-1β信号通路 IL-1α和IL-1βb 的生物活性由 IL-1R1(IL-1 type ...
IL-1 alpha (Interleukin 1 alpha) and IL-1 beta (Interleukin 1 beta), encoded by IL1A and IL1B, respectively, are implicated in numerous inflammatory responses and in tumor progression. The objective of this research was to assess the association of genetic polymorphisms of IL1A and IL1B ...
IL-1aandIL-1bRecruitDifferentMyeloidCellsPromote 系统标签: cellsmyeloidrecruitpromotedifferentalarmins ofJanuary14,2016.ThisinformationiscurrentasInflammationCellsandPromoteDifferentStagesofSterileRecruitDifferentMyeloidβandIL-1αIL-1DinarelloandRonN.ApteIdanCohen,ElenaVoronov,MalkaR.White,CharlesA.PelegRider,Yar...
IL-1aandIL-1bRecruitDifferentMyeloidCellsPromote 系统标签: cellsmyeloidrecruitpromotedifferentalarmins ofJanuary14,2016.ThisinformationiscurrentasInflammationCellsandPromoteDifferentStagesofSterileRecruitDifferentMyeloidβandIL-1αIL-1DinarelloandRonN.ApteIdanCohen,ElenaVoronov,MalkaR.White,CharlesA.PelegRider,Yar...
目的 研究白细胞介素(IL)-1A和IL-1B基因多态性及其与结核易感性之间的关系.方法 应用PCR-时间飞行质谱技术(PCR-MassARRAY)分析1032例结核病患者和1008例非结核病患者的IL-1A和IL-1B基因多态性,并通过统计学分析IL-1A和IL-1B各单核苷酸多态性(SNP)位点基因型与活动性结核病之间的关系.结果 在筛选出的5个IL...
il-1β(或il1b)不存在于健康个体的细胞中,并且在其引发炎症之前需要一系列细胞内事件(如caspase-1切割等产生活性的il1b),il1b仅在血液单核细胞,组织巨噬细胞和树突细胞等表达,il1b是促炎细胞因子,其在感染和炎症期间充当外周免疫应答的介质,但也涉及急性和慢性自身免疫疾病,糖尿病、疼痛和神经障碍等。对于il...
Association of IL1A and IL1B loci with primary open angle glaucoma. BMC Med. Genet. 11, 99.Mookherjee S, Banerjee D, Chakraborty S, Banerjee A, Mukhopadhyay I, Sen A, Ray K. Association of IL1A and IL1B loci with primary open angle glaucoma. BMC Med Genet 2010;11:99....
Lack of association betweenIL-1AandIL-1Bpromoter polymorphisms and multiple sclerosis Multiple sclerosis is an autoimmune and inflammatory disease of the CNS characterised by recurrent destruction of myelin which results in heterogeneous and unpredictable clinical manifestations. Although the factors able to...