IL-1RI直接与IL-1α或IL-1β结合,然后与IL-1R辅助蛋白(accessory protein) IL-1R3/IL-1R AcP偶联形成一个高亲合力的受体复合物,从而进行信号传导。小鼠白细胞介素1beta检测试剂盒IL-1 RII对IL-1β具有较高的亲合性,但作为诱捕受体(decoy receptor)发挥功能,负调控IL-1β的活性。IL-1ra作为竞争性抑制剂...
IL-1 beta重组蛋白/试剂盒 价格电议 起批量≥1 支 最小起订1支 供货总量1000支 发货地址北京市大兴区 建议售价￥5000/支 更新日期2024年12月16日 产品规格100ug 即时洽谈立即询价查看联系方式 收藏产品发送留言 VIP2年 北京百普赛斯生物科技股份有限公司高新技术企业A股 ...
Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions, giving IL-RA or IL-1 beta neutralizing antibodies potential t...
Guia S等研究发现在IL12RB1突变导致IL-12Rbeta1完全缺乏的患者中,NK细胞亚群明显减少,特别是对于IFN-γ的产生;从IL-12p40完全缺失的患者中也获得了类似的数据。此外,IL-12Rbeta1-和IL-12p40缺陷患者表达CD56的效应记忆T细胞亚...
英文别名:Interleukin-1 receptor type 2, IL-1R-2, IL-1RT-2, IL-1RT2, CD121 antigen-like family member B, CDw121b, IL-1 type II receptor, Interleukin-1 receptor beta, IL-1R-beta, Interleukin-1 receptor type II, CD121b 描述:Recombinant Human Interleukin-1 receptor type 2/IL-1R-2 ...
PROBLEM TO BE SOLVED: To obtain new polynucleotide having high identity with a nucleic acid encoding interleukin-1 receptor antagonist beta having a specific amino acid sequence, capable of providing the before material used for treating various dysfunctions and diseases.YOUNG PETER R...
Guia S等研究发现在IL12RB1突变导致IL-12Rbeta1完全缺乏的患者中,NK细胞亚群明显减少,特别是对于IFN-γ的产生;从IL-12p40完全缺失的患者中也获得了类似的数据。此外,IL-12Rbeta1-和IL-12p40缺陷患者表达CD56的效应记忆T细胞亚群的大小明显减少。因此,人类NK细胞需要体内IL-12来获得其全谱的功能反应性。 图片来...
3.Brikos C, Wait R, Begum S, O'Neill LA, Saklatvala J. Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components. Mol Cell Proteomics. 2007 Sep;6(9...
IL-1beta is a proinflammatory cytokine produced in a variety of cells including monocytes,tissue macrophages,keratinocytes and other epithelial cells. Both IL-1alpha and IL-1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range ...
roles in the regulation of the immune responses. Both IL-1α and IL-1β binds to the same receptor and has similar but not identical biological properties; The mature human IL-1β shares 96% amino acid sequence identity with rhesus and 67 % -78 % with canine, mouse and rat IL-1β....