Guia S等研究发现在IL12RB1突变导致IL-12Rbeta1完全缺乏的患者中,NK细胞亚群明显减少,特别是对于IFN-γ的产生;从IL-12p40完全缺失的患者中也获得了类似的数据。此外,IL-12Rbeta1-和IL-12p40缺陷患者表达CD56的效应记忆T细胞亚...
白细胞介素-1(interleukin-1,IL-1)是在感染和炎症状态下,由多种细胞产生的、有多方面生物学功能的细胞因子,其生物学作用十分广泛,主要包括参与介导炎症反应、调节免疫、调节机体代谢.IL-1分子重量为17.5KD,有两种类型:IL-1a和IL-1B,主要以IL-1B为主.IL-1受体(interleukin-1 receptor,IL-1R)包括Ⅰ型和Ⅱ型...
Guia S等研究发现在IL12RB1突变导致IL-12Rbeta1完全缺乏的患者中,NK细胞亚群明显减少,特别是对于IFN-γ的产生;从IL-12p40完全缺失的患者中也获得了类似的数据。此外,IL-12Rbeta1-和IL-12p40缺陷患者表达CD56的效应记忆T细胞亚群的大小明显减少。因此,人类NK细胞需要体内IL-12来获得其全谱的功能反应性。 图片来...
英文别名:Interleukin-1 receptor type 2, IL-1R-2, IL-1RT-2, IL-1RT2, CD121 antigen-like family member B, CDw121b, IL-1 type II receptor, Interleukin-1 receptor beta, IL-1R-beta, Interleukin-1 receptor type II, CD121b 描述:Recombinant Human Interleukin-1 receptor type 2/IL-1R-2 ...
Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions, giving IL-RA or IL-1 beta neutralizing antibodies potential therapeutical value...
Both IL-1α and IL-1β binds to the same receptor and has similar but not identical biological properties; The mature human IL-1β shares 96% amino acid sequence identity with rhesus and 67 % -78 % with canine, mouse and rat IL-1β. ...
重组小鼠IL-1β价格:￥1128/Standard产品详情:重组小鼠IL-1β 英文名称:Recombinant Murine IL-1beta 规格:2ug 价格:￥1,128 货号:211-11B-2ug RUO PROTEINS IL-1β is a proi... 包装规格:2ug 用途:科研研究 货号:211-11B-2ug 品牌:PeproTech ...
PROBLEM TO BE SOLVED: To obtain new polynucleotide having high identity with a nucleic acid encoding interleukin-1 receptor antagonist beta having a specific amino acid sequence, capable of providing the before material used for treating various dysfunctions and diseases.YOUNG PETER R...
3.Brikos C, Wait R, Begum S, O'Neill LA, Saklatvala J. Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components. Mol Cell Proteomics. 2007 Sep;6(9...
1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. IL-1 beta binds to IL-1 RI and IL-1 RII. The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction, and IL-1ra is a secreted molecule ...