We investigated the role of mitogen-activated protein kinase (MAPK) pathway in IL-1 β induced ASM proliferation in the rat. Rat tracheal ASM cells were dissociated and maintained in culture. We examined the effect of selective MAPK inhibitors, SB239063 (a p38 MAPK inhibitor), U0126 (a ...
IL-1 activation of NF-kappaB signaling pathway in neonatal rat after hypoxia/ischemia 来自 ResearchGate 喜欢 0 阅读量: 16 作者: X Hu,JR Perez-Polo 摘要: Perinatal hypoxia/ischemia (HI) is a common cause of neurological deficits in children. Our goal was to elucidate the underlying mechanisms...
The staining of cells that synthesized IL-1, which is not transported intracellularly via the endoplasmatic reticulum-Golgi pathway, generated a different, but distinct and reproducible staining pattern, IL-1 producing macrophages expressed intense nuclear immunofluorescence with additional reticular, ...
Downstream inflammatory mediators [tumor necrosis factor-± (TNF-±), interleukin-1 (IL-1), IL-6, intercellular adhesion molecule-1 (ICAM-1) and transforming growth factor-1 (TGF-1)] of the NF-B signaling pathway were investigated to evaluate the renal inflammatory response. Renal levels of...
In the present study, we have shown that IL-1β increased BDNF mRNA expression in hypothalamic neuron-enriched cultures whereas it reduced this expression in mixed cultures, i.e. containing astrocytes and neurons. Because functional relationships between stress and immunity signals are well documented...
In this study, we first systematically reported that RDTF functioned as an effective anti-inflammatory agent in a rat degenerative cervical intervertebral disc model by abolishing the activation of MAPK (JNK, ERK1/2 and p38) signaling pathway induced by IL-1β and TNF-α. As we known, IVD ...
The epithelial Na+ channel (ENaC) provides the main absorptive pathway of the distal large intestine. This study aimed to characterize regulatory influences of cytokines in rat late distal colon. After 6 h incubation with either IL1β, TNFα, IFNγ, or combinations of TNFα and IFNγ...
Thus the results of our study suggest that fetal hypoxia may prime male MGs through the activation of the NFκB signaling pathway. Interestingly, immune and inflammation pathways were also activated by fetal hypoxia in ODCs and A2B5+ cells. For example, the key cytokines Il1b and Il1a were...
Furthermore, the AG490 had lower serum levels of ET, TXB2, IL-6 and TNF-α and higher serum levels of NO, SOD, 6-keto-PGF1a and IL-10 than those in the PIH group. Conclusion: Our study provides evidence that inhibition of the JAK2/STAT3/SOSC1 signaling pathway could improve the ...
This signaling pathway is considered to promote VEGF and eNOS expressions30. Despite lacking definitive evidence of angiogenesis other than the early genetic response of VEGF and CD31 after LESW, the angiogenesis could increase the blood perfusion, then, increased blood perfusion could prevent ischemic...