Lisa Kraft, Tugs Erdenesukh, Martina Sauter & Karin Klingel Department of Cardiology, Berlin Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, 13353, Berlin, Germany Carsten Tschöpe Corresponding author Correspondence toKarin Klingel. Ethics decla...
In order to elucidate the signal transduction pathways responsible for IL-1beta regulation of MOR a qRT-PCR array was completed, revealing a significant role of the human p38 MAPK pathway. Next using signaling inhibitors, SN50 (NF-κB), PD98059 (MEK1/2) and SB203580 (p38 MAPK), using ...
This study aims to investigate the effects of FSTL1 in ovalbumin (OVA)-induced mice and macrophages on nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3)/interleukin-1 beta (IL-1 beta) signaling pathway.Wang, YanZhang, DongLiu, TianWang, Jun-feiWu, Jin-xiangZhao, Ji-ping...
Silver nanoparticles inhibit VEGF-and IL-1β-induced vascular permeability via Src dependent pathway in porcine retinal endothelial cells The aim of this study is to determine the effects of silver nanoparticles (Ag-NP) on vascular endothelial growth factor (VEGF)-and interleukin-1 beta (IL-1.....
signaling pathway hyaluronan biosynthetic process neutrophil chemotaxis sequestering of triglyceride positive regulation of fever generation lipopolysaccharide-mediated signaling pathway positive regulation of prostaglandin secretion response to lipopolysaccharide interleukin-1 beta production positive regulat...
p-p70S6K and MAP2 which were increased by IL-1βstimulation (P<0.05).CONCLUSION: IL-1βactivates PI3K-p85 by binding with IL-1RI to promote the activation and proliferation of neuron synapses via PI3K/Akt/mTOR signaling pathway, which might be one of the mechanisms in MTLE chronic progres...
Hyperthermia-induced heat shock activates the transcription factor c/EBP-beta and augments IL-6 production in human intestinal epithelial cells Background:Interleukin (IL)-6 production is increased in gut mucosa during sepsis and endotoxemia. The heat shock response augments IL-6 production under t....
Poor survival of transplanted dopaminergic (DA) neurons remains a serious obstacle to the success of cell replacement therapy as an alternative to the current treatments for Parkinson’s disease. We have examined the temporal release profile of an inflammatory cytokine, interleukin-1beta (IL-1β) ...
Signaling pathway of interest was identified based on high throughput sequencing results, in which the differentially expressed genes were verified by qRT-PCR, Western Blot, and immunofluorescence staining. Results 1 In vivo experiment: compared with the control group, the pulmonary collagen ...
A new approach of nano-metformin as a protector against radiation-induced cardiac fibrosis and inflammation via CXCL1/TGF-Β pathway Heba M. Karam Dina M. Lotfy Amira Abd-ElRaouf Naunyn-Schmiedeberg's Archives of Pharmacology (2024) Metformin activated AMPK signaling contributes to the alleviatio...