However, the signaling mechanisms remain to be elucidated. Here, we tested the hypothesis that IH activates the IL-1β and NFB/IL-6 pathway in primary macrophages using a state of the art in vitro model of IH.Methods: Bone marrow derived macrophages isolated from C57Bl/6J mice were exposed...
(PFC) that has been linked with the expression of the lethal-7 (let-7)miRNAfamily suspected to be part of the biological pathway in the inflammatory process (Wei et al., 2016). In thisanimal model, exercise such as running was seen as a protective factor inhibiting proinflammatory mediators...
Furthermore, we found that IL-1β signaling synergizes with type I IFN to suppress WNV replication in neurons, thus implicating antiviral activity of IL-1β within neurons and control of virus replication within the CNS. Our studies thus define the NLRP3 inflammasome pathway and IL-1β ...
2022年5月,吕安康主任医师在《Arteriosclerosis Thrombosis And Vascular Biology》杂志发表题名为“Caspase-8 Promotes Pulmonary Hypertension by Activating Macrophage-Associated Inflammation and IL-1β (Interleukin 1β) Production.”——C...
Life Sci Betulin attenuates kidney injury in septic rats through inhibiting TLR4/NF-κB signaling pathway PubMed: 26656467 Asian Pac J Trop Med Effect of SecinH3 on lung injury induced by sepsis of rats PubMed: 26706678 PLOS ONE Penehyclidine Hydrochloride Preconditioning Provides Cardioprotection ...
Protein Pathways Alzheimer's disease, Apoptosis, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, MAPK signaling pathway, NOD-like receptor signaling pathway, Prion diseases, Toll-like receptor signaling pathway, Type I diab...
G and A allele of the −3893 SNP, which may suggest the T allele of T-31C SNP to have the critical effect on GGCT haplotype. In future studies, it would be interesting to study the haplotypes effect on COX-2 and IL-6, which are downstream targets in the IL-1β signaling pathway...
et al. Associations between functional polymorphisms in the NFkappaB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease. Pharmacogenomics J. 14, 526–534 (2014). 36. Hwang, I. R. et al. Effect of interleukin 1 polymorphisms on gastric mucosal...
Accordingly, various approaches to anti-cancer strategies involve inhibition of the NFB signaling pathway [1]. Interestingly, NFB is converted into a pro-apoptotic factor upon stimulation with IL-1 + UVB. The persistence of this effect is ensured by sustained NFB activity [2] caused by ...
signaling pathway. From our study, the effective protec- tion of SF in OA chondrocytes in vitro is involved not only in the anti-apoptosis process but also in the anti- inflammatory effect. Conclusion Our findings indicate that SF can prevent apoptosis of chondrocytes in vitro, due to the ...