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Thus, the IL-1 pathway plays a key role in triggering RNA vaccine-associated innate signaling, an effect that was unexpectedly amplified by certain lipids used in vaccine formulations incorporating N1-methyl-pseudouridine-modified RNA to reduce activation of Toll-like receptor signaling. This is a ...
IL-1β通过非常规的蛋白质分泌途径分泌，可以旁分泌或系统分泌，主要由先天免疫系统的前哨细胞：单核细胞和巨噬细胞产生，也可以从上皮细胞、内皮细胞、成纤维细胞、滑膜细胞、神经元、肥大细胞以及胶质细胞如小胶质细胞和星形胶质细胞等细胞中释放。IL-1β的合成与释放受到非常严格的调控，免疫系统已经进化出几种机制...
Moreover, comparing canonical pathways by gene set enrichment analysis and the Ingenuity Pathway Analysis tool revealed that IL-1 counteracted TGF-β in the top six most confident pathways regulated by both cytokines. Interferon and IL-1 signaling, as well as two pathways involved in apoptosis ...
1. Introduction: The IL-33/IL-1RL1 pathway as a central nexus in asthma 2. The IL-33/IL-1RL1 pathway in asthma 3. Genetics of the IL-33/IL-1RL1 pathway 4. Towards precision medicine 5. Conclusion Declaration of Competing Interest Acknowledgements ReferencesShow full outline Cited by (82...
Pathway leading to SCF expression in primary human lung fibroblasts upon IL-1β treatment.Laurent ReberLinda VermeulenGuy HaegemanNelly Frossard
Kraft, L., Erdenesukh, T., Sauter, M.et al.Blocking the IL-1β signalling pathway prevents chronic viral myocarditis and cardiac remodeling.Basic Res Cardiol114, 11 (2019). https://doi.org/10.1007/s00395-019-0719-0 Download citation ...
相比之下,Ingenuity Pathway Analysis(IPA)软件通过提供更全面、更详细的功能注释和通路分析,在多组学数据集的集成分析方面具有优势。IPA拥有更大的数据库和更广泛的注释信息,可以识别更多的功能和途径相关性。此外,IPA提供了药物靶点预测和生物网络分析等先进功能,使人们能够进一步研究基因和途径的调节机制。
The current study indicates for the first time that the loss of METH-related cognitive decline can be attenuated by neutralizing IL-1 signaling. Our findings suggest a potential new therapeutic pathway for treatment of altered cognitive abilities that occur in METH abusing individuals....