Dagenais M, Dupaul-Chicoine J, Douglas T, Champagne C, Morizot A, Saleh M. The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis. Oncoimmunology 2017;6:e1287247....
Neuroinflammation, typified by elevated levels of interleukin-1 (IL-1) α and β, and deficits in proteostasis, characterized by accumulation of polyubiquitinated proteins and other aggregates, are associated with neurodegenerative disease independently and through interactions of the two phenomena. We in...
A. et al. Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis. Arthritis Rheum. 62, 3237–3248 (2010). Article CAS PubMed PubMed Central Google Scholar So, A., ...
O. Interleukin-1 beta-induced stimulation of insulin release in mouse pancreatic islets is related to diacylglycerol production and protein kinase C activation. Mol. Cell. Endocrinol. 111, 159–165 (1995). Article CAS PubMed Google Scholar Schumann, D. M. et al. The Fas pathway is involved...
These signals activate the NALP3-inflammasome pathway, which plays a central role in acute and chronic sterile inflammation. Here, we describe the essential components of the NALP3-inflammasome that control processing and release of IL-1beta. 展开 关键词:...
Hypersecretion of interleukin (IL)-1尾 plays a pivotal role in the pathogenesis of many of these disorders and explains a large part of the clinical manifestations of these multisystem diseases. Several drugs which block the IL-1 pathway have been developed. In this chapter, we summarize the ...
[118]. IL-1α expression is induced by TLR-mediated NF-κB activation; such activation has been observed in some LCH cases [119,120], with/without the presence of IL-1β [121]. All TLRs except TLR3 use the common MyD88-dependent pathway [122]. MyD88 is one of the adaptor proteins...
and NLRP12 can interact with apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC) and caspase-1, and the resulting complex is a sensor of cell injury called “inflammasome”, an interleukin (IL)-1β-processing platform that plays a crucial role in IL-1β matura...
The IL1RAP targeting antibody CAN04 can be safely administered to patients up to 10.0 mg/kg weekly, which was defined as the RP2D. Serum biomarkers supported target engagement and IL-1 pathway inhibition. Clinical trial registration NCT03267316. This is a preview of subscription content, acc...
27,47,50,51 These studies underscore the importance of the IL-1 pathway as a mediator of inflammation in KD. They suggest that IL-1 or its receptor may be reasonable targets for therapy during KD, particularly for IVIG-resistant patients. Of interest, IL-1β signalling prolongs neutrophil ...