Dagenais M, Dupaul-Chicoine J, Douglas T, Champagne C, Morizot A, Saleh M. The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis. Oncoimmunology 2017;6:e1287247....
Interleukin 1 (IL-1) has important functions in innate and adaptive immunity. Blocking IL-1 action has clinical efficacy in many inflammatory diseases, including type 2 diabetes mellitus. Here, the authors review the mechanisms of IL-1 action that lead t
Members of the IL-1 family of cytokines have been implicated in several autoimmune diseases, including rare hereditary syndromes and more frequent diseases such as gout. Once processed and activated, IL-1α and IL-1β promote inflammation, monocyte and n
These signals activate the NALP3-inflammasome pathway, which plays a central role in acute and chronic sterile inflammation. Here, we describe the essential components of the NALP3-inflammasome that control processing and release of IL-1beta. 展开 关键词:...
Hypersecretion of interleukin (IL)-1尾 plays a pivotal role in the pathogenesis of many of these disorders and explains a large part of the clinical manifestations of these multisystem diseases. Several drugs which block the IL-1 pathway have been developed. In this chapter, we summarize the ...
Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease. In this decade, interleukin-1 family members have been expanding and evidence
Thisarticleelaborates thesignaltransductionpathwayofinterleukin-1(IL-1)and itsregulatorymechanismonembryoimplantation. 本文论述了白细胞介素-1(IL-1)的信号转导通路及其在胚胎植入中的调节作用。 www.ilib.cn 7. Tollandinterleukin-1receptor(TIR)domainswereoriginallydescribedfromcomparisonsofproteinsfoundinmammalsan...
Interleukin 1 beta (IL-1 ) is often associated with thyroidal autoimmune diseases. This cytokine has been largely described to trigger an important biological signalling pathway: the sphingomyelin/ceramide pathway. In this report we show that IL-1 induces ceramide formation and sphingomyelin degra...
IL-1 signaling pathway Once IL-1α or IL-1β binds to the IL-1R1 chain, a ligand-induced conformational change facilitates recruitment of IL-1RAcP, the receptor chain required to form a functioning signaling IL-1 R complex.50, 51, 52 Subsequently, the trimeric IL-1 R complex recrui...
However, there are examples where some cytokines appear to have dual functions through an additional intracellular role1. One of the most important cytokine families in the host response to infection is the interleukin-1 (IL-1) superfamily, which consists of 11 members of both pro- and anti-...