IL 3 signaling pathway(1)|il|pathway|signalingInterleukin-3 promotes the proliferation and differentiation of hematopoietic cells through binding to its receptor. The receptor for IL-3 is a heterodimer with a ligand-specific a
HEK-Blue™ IL-3 cellswere generated by stable transfection of the human embryonic kidney HEK293 cell line with the gene encoding the human IL-3 receptor (IL-3Rα chain and common β-chain (CD131)) and STAT5 to obtain a fully active IL-3 signaling pathway. In addition, a STAT5-indu...
The carboxy terminus of the 尾 subunithas been shown to be necessary for activation of the MAP kinase signaling pathway. Although the IL-3 receptor has no intrinsic kinase activity, stimula- tion with IL-3 leads to tyrosine phosphorylation of the JAK/Tyk 2 family mem- ber, JAK2, which in...
Enables cytokine activity; growth factor activity; and interleukin-3 receptor binding activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; monocyte differentiation; and regulation of phosphate metabolic process. Located in extracellular space. Is expressed...
货号AHC0832 Price (CNY) 4,312.00 500 µg 下单后预计有货时间 03-Jun-2025 查看价格 批量或定制请求 已发表图片 (2) Application Created with Sketch. 图:1/2 IL-3 Antibody (AHC0832) in ELISA Nature communications 2020 -Fig. 1 Ccl5 expression from T cells is repressed by RUNX/CBFbeta comp...
Differential requirements of TCR signaling in homeostatic maintenance and function of dendritic epidermal T cells. J. Immunol. 195, 4282–4291 (2015). CAS PubMed Google Scholar Voehringer, D., Liang, H. E. & Locksley, R. M. Homeostasis and effector function of lymphopenia-induced ‘memory-...
IFNγ may render the cells more responsive to IL-3 by up-regulating the IL-3R, or the synergism may be caused by some post-receptor mechanism along the signaling pathway. Interestingly, IL-3 has recently been shown to activate JAK2 kinase,35 which has also been implicated in IFNγ ...
The Ras family small GTPase Rap1 is activated by hematopoietic cytokines, such as interleukin (IL)-3, to induce β1 integrin-mediated cell adhesion or by the BCR/ABL fusion tyrosine kinase to stimulate the MEK/Erk signaling pathway. Here, we demonstrate
in order to lay a foundation for exploring the regulation mechanism of IL-6/STAT3/SOCS3 signaling pathway in ulcerative colitis carcinogenesis.AOM/DSS modeling method was used to establish animal models of ulcerative colitis carcinogenesis; colonic mucosa specimens were collected at different time points...
Mechanism of IL-33 regulation of epithelial-mesenchymal transformation induced by cigarette smoke extract through TGF-β1/Smad3 signaling pathway 在线阅读 免费下载 引用 收藏 分享 摘要 目的探讨IL-33在烟草提取物(CSE)诱导细胞上皮-间质转化(EMT)形成过程中的作用机制。方法将人支气管上皮细胞(16HBE)分...