IL-2对B细胞的生长及分化均有一定的促进作用。活化的或恶变的B细胞表面表达高亲和力IL-2R，但是密度较低；较高密度的IL-2可诱导B细胞生长繁殖，促进抗体分泌，并诱使B细胞由分泌IgM向着分泌IgG2转换。4.对巨噬细胞的作用 人类单核－巨噬细胞表面在正常时有少量的IL-2Rβ链表达，但是受到IL-2、 IFN-γ或其...
6. Sarah H. Ross and Doreen A. Cantrell, Signaling and Function of Interleukin-2 in T Lymphocytes. Annu. Rev. Immunol.
【3】https://www.rndsystems.com/cn/pathways/il2-signaling-pathways
另外，与其他细胞因子一样，IL-2信号传递同样受到细胞因子信号抑制物（Suppressor of cytokine signaling，SOCS） 家族蛋白的负调控。SOCS-3磷酸化可以抑制STAT-5磷酸化和T细胞增值，进而调控IL-2应答[25,31]。四，IL-2的功能及生物学活性 IL-2是T细胞衍生的常见细胞因子。它在T细胞、B细胞、NK细胞、巨噬细胞和少...
典型通路报告期2 signalingil 2信号.pdf,Canonical Pathway Report Date: 2016-02-14 Report Version: FFFF.svnRevision.FFFF Content Version: 26127183 (Release Date: 2015-11-30) Canonical IL-2 Signaling Pathway: Description: Interleukin 2 (IL-2) is a growth fac
另外,与其他细胞因子一样,IL-2信号传递同样受到细胞因子信号抑制物(Suppressor of cytokine signaling,SOCS) 家族蛋白的负调控。SOCS-3磷酸化可以抑制STAT-5磷酸化和T细胞增值,进而调控IL-2应答[25,31]。 四,IL-2的功能及生物学活性 IL-2是T细胞衍生的常见细胞因子。它在T细胞、B细胞、NK细胞、巨噬细胞和少突...
Consonni F, Favre C and Gambineri E (2021) IL-2 Signaling Axis Defects: How Many Faces? Front. Pediatr. 9:669298. Lidia Yshii et al, Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammati...
[2] Liao, W., Lin, J.-X., & Leonard, W. J. (2013). Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy. Immunity, 38(1), 13–25. [3] Gaffen, S. L. (2001). SIGNALING DOMAINS OF THE INTERLEUKIN 2 RECEPTOR. Cytokine, 14(2), 63–77. ...
Defective interleukin-6 (IL-6) signaling has been associated with Th2 bias and elevated IgE levels. However, the underlying mechanism by which IL-6 prevents the development of Th2-driven diseases remains unknown. Using a model of house dust mite (HDM)-in
FOXP3+ regulatory T cells (Treg) are indispensable for immune homoeostasis and for the prevention of autoimmune diseases. Interleukin-2 (IL-2) signalling is critical in all aspects of Treg biology. Consequences of defective IL-2 signalling are insufficie