37]. The IL-2:IL-2R complex can signal via three major pathways, each activating different downstream transcriptional regulators [27,38,39]. Depending on the downstream signalling pathway, PI3K (PI3K-AKT-mTOR pathway
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics 30, 923–930 (2014). Article CAS PubMed Google Scholar Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2....
Despite differences in T cell responses induced by interleukin (IL)-2 and IL-7, both cytokines modulate T cell functions by activation of signal transducer... LA Rosenthal,KD Winestock,DS Finbloom - 《Cellular Immunology》 被引量: 100发表: 1997年 An Essential Role of Sialylated O-Linked Sug...
The FMDV 2A self-cleavage peptide and downstream α-factor signal sequence for secretion were used to generate a multicistronic cassette linking the pig IL-2 and FBC genes. Then, to construct a fusion gene of pig IL-2, 2A-α, factor and FBC (PIL-2/2A-α/FBC), six oligodeoxynucleotide ...
(IL-2Rα) and CD215 (IL-15Rα). The binding of IL-2 and IL-15 to their heterodimeric or heterotrimeric receptors leads to the activation of a signaling cascade through tyrosine kinases of the Janus family (JAK1 and JAK3) and signal transducer and transcription activator 5 (STAT5) [1]...
Regulation of IL-2 gene expression through CD28 is dependent on cooperativity between cis -acting promoter sequencesT lymphocytes can be induced to produce interleukin (IL)-2 and proliferate upon T cell receptor (TcR) occupancy together with a CD28-induced co-stimulatory signal. The T cell ...
complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-...
By analysis of deletion mutants, we identified three DNA sequences extending from -73 to -89, -217 to -255, and -263 to -279, designated IL-2 ... D,B,Durand,... - 《Mol.cell.biol》 被引量: 430发表: 1988年 Analysis of interleukin-2-dependent signal transduction through the Shc/...
Signal transducers and activators of transcription (Stats) are activated by tyrosine phosphorylation in response to cytokines, and are thought to mediate many of their functional responses. Stat6 is activated in response to interleukin (IL)-4 and may contribute to various functions including mitogenesis...
IL-2 was first identified as a growth factor capable of driving the expansion of activated human T cell populations. In the more than 40 years since its discovery, a tremendous amount has been learned regarding the mechanisms that regulate the expression of both IL-2 and its cell surface rece...