Consequently, a cDNA clone was obtained encoding guinea pig IL-2 of 520 bp in length, which contained a complete open reading frame. Alignment of the amino acid sequence with human IL-2 indicates that guinea pig IL-2 is composed of 20 amino acids (aa) of a signal peptide and 132 aa ...
37]. The IL-2:IL-2R complex can signal via three major pathways, each activating different downstream transcriptional regulators [27,38,39]. Depending on the downstream signalling pathway, PI3K (PI3K-AKT-mTOR pathway
the IL-2 receptor alpha, beta and gamma subunits. The intermediate-affinity IL-2 receptor complex, which lacks the alpha subunit, but contains both the beta and gamma subunits, is also capable of transducing the IL-2 signal. In T cells, the beta and gamma subunits are shared with the IL...
hematopoiesis, metabolism, and oncogenesis [1]. Classic IL-6 signaling is initiated by the binding of IL-6 to the membrane-bound IL-6-specific receptor α chain (IL-6R). The IL-6/IL-6R complex triggers its association with the signal-transducing subunit, glycoprotein 130 (GP...
byRT-PCRcloningcolonyIL-2 cDNAfragment.TheDNAfragmentswereanalyzed useDNAStarsoftwarebetweendifferentspeciesidentityforcomparison.SequenceanalysisshowedthatIL-2 genehasanopenreadingframesfor 432 nucleotideacids,encoding 143 aminoacidsandmostofsignal peptide,comparedwithpublishedonGenbank,thenucleotideidentitywas 98.8...
IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A. 英文别名: Interleukin-22,IL-22,Cytokine Zcyto18,IL-10-related T-cell-derived-inducible factor,IL-TIF,...
which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is instead secreted alongside caspase-1 via an alternate and incompletely understood mechanism. IL-1 beta signals via the IL-1RI, which is shared with IL-1 alp...
signal transduction protein 2, related sequence 1 ST2 St2 St2-rs1 ST2L T1 T1 gene T1/ST2 基因序列:NCBI_Gene:17082 蛋白序列: UniprotKB:P14719 UniprotKB:G3UYU3 UniprotKB:Q3UM53 UniprotKB:Q5D095 小鼠Mouse Il1rl1 靶点分子功能(预测)
We previously demonstrated a two-signal requirement for the activation of the human T cell lines Jurkat and HUT 78. Interleukin 2 (IL 2) production by these lines can be induced by phytohemagglutinin (PHA), T3 antibodies, or calcium ionophores, but only in combination with phorbol myristate ac...
RNA-seq data generated in this study have been deposited in the Genome Sequence Archive database at https://bigd.big.ac.cn/gsa/browse/CRA015275. Source data are provided with this paper. References Labanieh, L. & Mackall, C. L. CAR immune cells: design principles, resistance and the ...