Cell Signaling Pathways› IL-22 Pathway IL-22 (Interleukin-22) is a member of the IL-10 family of cytokines. IL-22 was identified as a T-cell-derived inducible factor produced by IL-9-activated murine T cells. It is an important effector molecule for act...
IL-22 activates the STAT3 signaling pathway in GBM cell lines.Hussein AkilAmazigh AbbaciFabrice LallouéBarbara BessetteLéa M. M. CostesLinda DomballeSandrine CharreauKarline GuilloteauLucie KarayanTaponFrançoisXavier Bernard
22 to its receptor complex induces signal transduction, particularly via the JAK-STAT pathway. In addition to the membrane-bound IL-22R1/IL-10R2 complex, a soluble single-chain IL-22 receptor termed IL-22BP has been found to antagonize IL-22 binding and signaling. IL-22 appears not to ...
Several components of mucosal immunity are disrupted in CD. These include epithelial barrier integrity, mucous production and cell turnover, the production of antimicrobial peptides and proteins (AMPs), and the release of metal ion scavengers that contribute to nutritional immunity21,22,23. Nutritional...
Interleukin-22 promotes the proliferation and migration of hepatocellular carcinoma cells via the phosphoinositide 3-kinase (PI3K/AKT) signaling pathway Fizzah Mansur Tanzeela Arshad Sobia Manzoor Molecular Biology Reports (2023) Gut Microbiota Resilience Mechanisms Against Pathogen Infection and its Role...
The changed Trp metabolism by pectin supplementation activated the AhR/IL-22/STAT3 signaling pathway in jejunal mucosa of piglets Microbial derived tryptophan catabolites (indole compounds) are ligands for the AhR and act on the AhR in lymphoid cells. Therefore, we investigated the effect of pectin...
ConclusionsIL⁃33 promotes ILC2 and macrophage recruitment during peritoneal sepsis. And the recruitment of peritoneal ILC2 depends on IL⁃33/ST2 signaling pathway. Peritoneal ILC2 derived cytokines IL⁃9 and IL⁃13 e...
Next, we explored the molecular mechanisms by which IL-17 and IL-22 promote KC stemness. The principal mediators of IL-17 and IL-22 signaling are NF-κB and STAT3, respectively, whereas the MAPK pathway has been implicated in a tissue context-dependent manner (Amatya et al., 2017, Dudak...
signaling pathway but was not correlated with the canonical AMPK pathway. In the coculture system, the metformin pretreatment group showed higher T cell activation and better T cell killing function than the control group....
(2011) Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling. Hepatology 54(3):979-988.7. Qiang Z, et al. (2020) Nrf2 and STAT3 Alleviates Ferroptosis-Mediated IIR-ALI by Regulating SLC7A11...