We hypothesized that vitamin D could reduce IL-21 function; define as expression, signaling and levels of IL-21; in a SLE Mestizo cohort. The main objective of this study was to determine if vitamin D supplementation has an effect on IL-21 levels and its signaling pathway in B-lymphocytes...
21plays an important role in autoimmune diseases ，inflammatory diseases and cancer.This article mainly reviews the current research status of IL -21signaling pathways and functions ，as well as the research progress of pathogenesis in tumors and hypertension.［Key words ］Cytokine ；IL -21；Immune ...
IL-21R has been shown to activate the Janus kinase/signal transducers and activators of transcription signaling pathway upon ligand binding. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, natural killer, and...
关键词白细胞介素21;JAK/STAT信号通路;免疫性血小板减少症中图分类号R558.2 文献标识码Adoi:10.7534/j.issn.1009.2137.2018.03.038Changes of IL-21 and Its Mediated JAK/STAT Signaling Pathway inZHANG Qian+,BAI Hai,YU Xiao一胁f,WU Bing,以ⅣYao—Zhu,WANG Cun.Bang,ZHA0 Li.Ping,LI Wen.Bo,XU n...
IL21 and its receptor activate JAKSTAT signaling pathway. IL21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL21 plays a role in the proliferation and maturation of NK, B and T cell populations.白介素21是多效免疫调节活性的细胞因子,与其受体结合后可以调节并...
IL-21 is a class I cytokine of the common gamma chain family of cytokines and signals through the IL-21R complex to activate the JAK/STAT (Janus Kinase/Signal Transducers and Activators of Transcription) signaling pathway. Activation of the JAK/STAT pathway by IL-21 promotes tra...
IL-21 is a class I cytokine of the common gamma chain family of cytokines and signals through the IL-21R complex to activate the JAK/STAT (Janus Kinase/Signal Transducers and Activators of Transcription) signaling pathway. Activation of the JAK/STAT pathway by IL-21 promotes tran...
Receptors in the Jak/STAT Pathway Th17 Cells Th22 Cells Related Products All Products for IL-21R IL-21R Primary Antibodies IL-21R Proteins and Enzymes IL-21R cDNA Clones Associated Pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types IL-21 Sign...
Moreover, lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) acted as a sponge of miR-125a to modulate the IL-21R signaling pathway in GC cells and represented a risk factor for survival and recurrence in patients with GC. Taken together, the findings of this study reveal...
To elucidate how IL-21 promoted miR-29 expression, we assessed whether it regulated early steps in miR-29 biogenesis. Quantification of pri-miR-29 transcripts revealed that IL-21 promoted the first step in the miR-29 biogenesis pathway as stimulation with IL-21 increased expression of pri-miR...