IL-21R has been shown to activate the Janus kinase/signal transducers and activators of transcription signaling pathway upon ligand binding. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, natural killer, and...
Its private receptor, IL-21R, has been shown to activate the Janus kinase/signal transducers and activators of transcription signaling pathway upon ligand binding. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, ...
关键词白细胞介素21;JAK/STAT信号通路;免疫性血小板减少症中图分类号R558.2 文献标识码Adoi:10.7534/j.issn.1009.2137.2018.03.038Changes of IL-21 and Its Mediated JAK/STAT Signaling Pathway inZHANG Qian+,BAI Hai,YU Xiao一胁f,WU Bing,以ⅣYao—Zhu,WANG Cun.Bang,ZHA0 Li.Ping,LI Wen.Bo,XU n...
IL-21 is a class I cytokine of the common gamma chain family of cytokines and signals through the IL-21R complex to activate the JAK/STAT (Janus Kinase/Signal Transducers and Activators of Transcription) signaling pathway. Activation of the JAK/STAT pathway by IL-21 promotes tran...
In order to block the IL-21 signaling pathway, a high affinity humanized antibody was developed to directly target both human (KD: 2.02 nM) and mouse (KD: 16.72 nM) IL-21R [14]. Previous studies showed that the antibody ATR-107 significantly reduces blood anti-dsDNA antibody level and ki...
IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21 is expressed in activated T cells, and HL-60 and THP-1 cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations. 产品留言 标题 联系人 联系电话 内容 验证码 点击换一...
IL12 signaling pathway References Coquet JM, et al. (2007) IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol. 178(5):2827-34. Wei L, et al. (2007) IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent ma...
IL-21 signaling primarily activates the Jak/STAT pathway with STAT1 and STAT3 being the predominant targets (de Totero et al., 2008). It was initially proposed that IL-21 was also a Th17-derived cytokine and was required for Th17 differentiation and development of EAE (Korn et al., 2007,...
IL21 and its receptor activate JAKSTAT signaling pathway. IL21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL21 plays a role in the proliferation and maturation of NK, B and T cell populations.白介素21是多效免疫调节活性的细胞因子,与其受体结合后可以调节并...
To elucidate how IL-21 promoted miR-29 expression, we assessed whether it regulated early steps in miR-29 biogenesis. Quantification of pri-miR-29 transcripts revealed that IL-21 promoted the first step in the miR-29 biogenesis pathway as stimulation with IL-21 increased expression of pri-miR...