Tumorigenesis is a multistep, complicated process, and many studies have been completed over the last few decades to elucidate this process. Increasingly, many studies have shifted focus toward the critical role of the tumor microenvironment (TME), which consists of cellular players, cell-cell ...
2023年8月18日,来自美国基因泰克公司Frederic J. de Sauvage研究组在学术期刊《细胞-干细胞》发表了标题为”Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells.“的研究成果。发现肾上腺素能神经通过3型先天淋巴细胞(ILC3s)分泌的IL-22信号传导调节肠道再生。
2021年3月21日，来自哈佛大学Laurie H. Glimcher团队在Nature Immonology 上发表题为Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias的文章。该研究发现在应激诱导性以及MDSs贫血中，IL22可以促进红系祖细胞凋亡，导致贫血；阻滞IL22途径可以逆转贫血。作者首先用造血细胞特异性单...
【5】Chiang H Y, Lu H H, Sudhakar J N, et al. IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence[J]. Nature communications, 2022, 13(1): 1-19. 【6】Gaudino S J, Beaupre M, Lin X, et al. IL-22 receptor signaling in Paneth cells ...
日前,德国汉堡-埃彭多夫大学医学中心和美国耶鲁大学医学院等合作,在Nature Communications杂志发表了题为:TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer 的研究论文。 该研究在体外实验中证实TGF-β信号传转导促进Th17细胞产生IL-22,还提供了第一个体内动物实验,证实TGF...
et al. Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism. FEBS Lett. 582, 2985–2992 (2008). Article CAS PubMed Google Scholar Yoon, S. I. et al. Structure and mechanism of receptor sharing by the IL-10R2 common chain. Structure...
因此,CD4 + T细胞(特别是Th17细胞)中的TGF-β信号传导促进产生IL-22的Th17细胞的出现,从而促进小鼠的肿瘤发生。然而,产生IL-22的单个T细胞不依赖于TGF-β信号传导。最终作者证明了TGF-β通过AhR诱导和PI3K信号传导促进Th17细胞中IL-...
图片来源于文献:Structural Basis of IL-1 Family Cytokine Signaling 图1 . IL-1信号通路图 IL-10 通路 IL-10家族中有9个成员,包括IL-10和IL-20亚家族成员IL-19、IL-20、IL-22、IL-24和IL-26;以及其他相关细胞因子IL-28A、IL-28B和IL-29,主要是根据它们的结构相似性、受体和下游信号而被归为一组。
22 signaling that blunts AMP responses and barrier repair. The combined effects of nutritional immunity and stress-induced impairment of protective IL-22 responses create a favorable niche for AIEC expansion. These deficiencies are correctable using either exogenous IL-22, or by blocking stress-induced...
Binding of IL-22 to its receptor complex induces signal transduction, particularly via the JAK-STAT pathway. In addition to the membrane-bound IL-22R1/IL-10R2 complex, a soluble single-chain IL-22 receptor termed IL-22BP has been found to antagonize IL-22 binding and signaling. IL-22 ...