如A图所示,人IL21-Fc可有效抑制B-hIL21R小鼠中的肿瘤生长,表明B-hIL21R小鼠是一种有效的、可用于IL21细胞因子或融合蛋白类抗体药物的临床前体内药效评价模型。数值以平均值±SEM表示。 参考文献 [1] Leonard, W.J. & Wan, C.K. IL-21 Signaling in Immunity. F1000Res 5 (2016). 百奥动物还在持续...
如A图所示,人IL21-Fc可有效抑制B-hIL21R小鼠中的肿瘤生长,表明B-hIL21R小鼠是一种有效的、可用于IL21细胞因子或融合蛋白类抗体药物的临床前体内药效评价模型。数值以平均值±SEM表示。 参考文献 [1] Leonard, W.J. & Wan, C.K. IL-21 Signaling in Immunity....
IL-21R信号通路通过降低IL-2的表达间接抑制Treg的免疫抑制功能。IL-21可抑制幼稚CD4+T细胞中肿瘤介导的FOXP3,直接阻断T细胞分化成Treg。点击下方的产品货号,直达官网详情页供您了解产品信息 参考文献 1.IL-21 sIgnaling in Immunity. 2.Tumor Microenvironment:The role of interleukins-Part A. 3.The role of IL...
IL-21R信号通路通过降低IL-2的表达间接抑制Treg的免疫抑制功能。IL-21可抑制幼稚CD4+T细胞中肿瘤介导的FOXP3,直接阻断T细胞分化成Treg。 参考文献:1.IL-21 sIgnaling in Immunity. 2.Tumor Microenvironment:The role of interleukins-Part A. 3.The role of IL-21 in Immunity and Cancer. ...
Signaling pathwaysgamma c Cytokine familyJAK-STAT pathwaysIL-21 is an immunomodulatory cytokine produced by natural killer (NK) cells and T cells that has pleiotropic roles in immune and nonimmune cells. IL-21 can modulate innate and specific immunity......
of lymphocyte function. Nature. 2000;408:57-63. [2]孙稳平, 李云岗, 王会波. 白细胞介素21及其研究进展. 动物医学进展. 2007;28:74-77.[3]Habib T,Senadheera S,Weinberg K,et al.The common gamma chain(gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-...
[2]孙稳平, 李云岗, 王会波. 白细胞介素21及其研究进展. 动物医学进展. 2007;28:74-77. [3]Habib T,Senadheera S,Weinberg K,et al.The common gamma chain(gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3.Biochemistry,2002...
[2]孙稳平, 李云岗, 王会波. 白细胞介素21及其研究进展. 动物医学进展. 2007;28:74-77. [3]Habib T,Senadheera S,Weinberg K,et al.The common gamma chain(gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3.Biochemistry,2002...
2. Luo, W., F. Weisel, and M.J. Shlomchik, B cell receptor and CD40 signaling are rewired for synergistic induction of the c-Myc transcription factor in germinal center B cells.Immunity, 2018. 48(2): p. 313-...
In addition, blocking the IL-21 signaling pathway with anti-IL-21 antibodies or IL-21R-Fc fusion proteins has shown a therapeutic role, impairing the symptoms of autoimmune diseases Author's contributions Di Long wrote the manuscript; Yongjian Chen, Haijing Wu, Ming Zhao and Qianjin Lu ...