Conclusion: IL-18 promotes the proliferation of squamous cell carcinoma of the skin, it may be related to the down-regulation of TRPV4 and activation of Smad7 signaling pathway.金蝉王万卷李静吴惠林房秀萍Progress in Modern Biomedicine
In addition, these cells can be used for screening antibodies or small molecule inhibitors targeting the IL-18 pathway. IL-18 is a pro-inflammatory cytokine that causes a wide variety of biological effects associated with infection, inflammation, and autoimmune processes [1, 2]. More details ...
et al. Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory. Proc. Natl. Acad. Sci. U. S. A. 107, 9777-9782, (2010). 23. Gattinoni, L. et al. Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem ...
In an effort to identify alternative cytokine pathways for immunotherapy, we found that components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. However, recombinant IL-18 previously did not...
'The treatment of psoriasis remains elusive, underscoring the need for identifying novel disease targets and mechanism-based therapeutic approaches. We recently reported that the PI3K/Akt/mTOR pathway that is frequently deregulated in many malignancies is also clinically relevant for psoriasis. We also ...
6.Cleveland,M.G.,Gorham,J.D.,Murphy,T.L..Tuomanen,E.and Murphy,K.M.(1996)″Lipoteichoic acid preparations of Gram-positive bacteriainduce interleukin-12 through a CD 14-dependent pathway″Infect Immun 64,1906-12. 7.Dinarello CA.(1996)″Biologic basis for interleukin-1 in disease.″Blood...
2.重庆医科大学口腔医学系）肿瘤是威胁全球人类身体健康的一类重大疾病，其病因复杂，并且每年的发病人数众多m。匕丨细胞介素18 (IL-18),以前称为干扰素y(IFN-y)诱导 因子，于IL-1家族.能够诱导IFN-7产生、激活自然 杀伤（N K)细胞和毒性T淋巴细胞（C T U、诱导辅 助T细胞（T h),从而在机体抗感染、抗炎...
pathway activation of protein kinase B activity interferon-gamma production interleukin-6 production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-17 production positive regulation of natural ...
Blocking the janus-activated kinase pathway reduces tumor necrosis factor alpha-induced interleukin-18 bioactivity by caspase-1 inhibition[J]. Arthritis Res Ther, 2014,16(2):R102. DOI: 10.1186/ar4551 . 返回引文位置Google Scholar 百度学术 万方数据 [11] Qi YY , Lu C , Ju Y ,et al. ...
It is noteworthy that Bcl-3, inducible by IL-22 in various cell types [151,152], fine-tunes activation of keratinocytes by the STAT3 pathway [151]. In fact, il22-/- mice display reduced [153] and IL-22-Fc-treated wiltyp mice enhanced imiquimod-induced psoriasis [154]. In agreement ...