Finally, plasma IL-18 levels were significantly elevated in patients with heart failure and were higher in those who died at follow-up than in survivors. The results suggest a potential role for the immunoinflammatory IL-18 signaling pathway in the pathophysiology of heart failure and identify ...
1 | Regulation of the IL-18 signaling axis in the TME. 然而,一项2009年的重组人源IL-18用于治疗转移性黑色素瘤的Ⅱ期临床试验结果显示:IL-18的临床治疗效果十分有限[14]。2018年,已有文献显示在多发性骨髓瘤中,高水平的IL-18将导致免疫抑制性的MDSC浸润,并与肿瘤的不良预后相关[15]。而Aaron Ring研究...
Our results demonstrated that the IL-18Rα-mediated signaling pathway plays critical roles in CD4+T cells and APCs and responded more quickly to IFN-γ and IL-18 than TLR4 stimulation in the pathogenesis of LPS-induced AKI. 展开 关键词: acute renal failure cytokine CD4+T cells ...
Thus, in the current study, we tested our hypotheses that the IL-18 inflammatory signal pathway plays a key role in radiation-induced cell and tissue damage and dysfunction. IL-18BP counters IL-18 activation and therefore may mitigate/treat IL-18-mediated multi-organ injury and increase ...
发布时间:2019-08-03 23:19 原文链接: IL17SignalingPathway Inflammation is a complex response involving many different cells and signaling molecules, including the secretion of the cytokine IL-17 by activated T cells. IL-17 secretion is restricted to specific subsets of T cells but the receptor ...
18Rb. IL-18R signaling plays a critical role in Th1 differentiation and effector function, and results in the increased expression of IFN gamma, TNF alpha, and Fas ligand from T cells and NK cells. IL-18 has also been found to synergize with IL-23 in the development and function of...
18Rb. IL-18R signaling plays a critical role in Th1 differentiation and effector function, and results in the increased expression of IFN gamma, TNF alpha, and Fas ligand from T cells and NK cells. IL-18 has also been found to synergize with IL-23 in the development and function of...
IL-17 signaling pathway has an ethnicity-specific effect in LSCC where it is upregulated in the Chinese while not in the Caucasians and IL17RC might play a key role. Targeting genes located in the IL-17 signaling pathway may be beneficial for Chinese LSCC patients. 展开 关键词: IL-17 ...
Phospholipase D signaling pathway is involved in lung cancer-derived IL-8 increased osteoclastogenesis Hsu YL,Hung JY,Ko YC,et al.Phospholipase D signalingpathway is involved in lung cancer-derived IL-8 increasedosteoclastogenesis. Carcinogenesis . 2010... YL Hsu,JY Hung,YC Ko,... - 《...
近日,宁夏医科大学总医院医学研究所科研团队在Communications Biology发表了题为Interleukin-33 promotes intrauterine adhesion formation in mice through the mitogen-activated protein kinasesignaling pathway的研究论文。本文通过小鼠子宫内膜类器官模型和RNA测序技术,揭示了IL-33在IUAs形成中的作用机制,并为临床治疗IUAs提...