Finally, plasma IL-18 levels were significantly elevated in patients with heart failure and were higher in those who died at follow-up than in survivors. The results suggest a potential role for the immunoinflammatory IL-18 signaling pathway in the pathophysiology of heart failure and identify ...
1 | Regulation of the IL-18 signaling axis in the TME. 然而,一项2009年的重组人源IL-18用于治疗转移性黑色素瘤的Ⅱ期临床试验结果显示:IL-18的临床治疗效果十分有限[14]。2018年,已有文献显示在多发性骨髓瘤中,高水平的IL-18将导致免疫抑制性的MDSC浸润,并与肿瘤的不良预后相关[15]。而Aaron Ring研究...
IL-1家族细胞因子通过与受体亚基结合激活细胞内信号通路,如IL-1RI/IL-1R1、IL-18Rα/IL-1R5、IL-1Rrp2/IL-1R6或ST2/IL-1R4,然后募集一个辅助受体来形成活性受体复合物。由IL-1α、IL-1β、IL-18、IL-33、IL-36α、IL-36β或IL-36γ触发的信号级联激活MAPK和NF-κB,导致促炎因子、趋化因子和炎症...
It is secreted by activated monocytes, macrophages, epithelial cells, and keratinocytes via a non-classical pathway.IL-18 Receptor is expressed on Th1, but not naive CD4 T cells or Th2, as well as subsets of NK cells and neutrophils. The heterodimeric receptor is made up of a ...
Thus, in the current study, we tested our hypotheses that the IL-18 inflammatory signal pathway plays a key role in radiation-induced cell and tissue damage and dysfunction. IL-18BP counters IL-18 activation and therefore may mitigate/treat IL-18-mediated multi-organ injury and increase ...
KIF20A 通过激活 IL-17 信号通路促进三阴性乳腺癌进展 《Biochemical and Biophysical Research Communications》:KIF20A Promotes Triple-Negative Breast Cancer Progression via Activation of the IL-17 Signaling Pathway 编辑推荐: 推荐 三阴性乳腺癌(TNBC)缺乏有效靶向治疗且预后差。研究人员探讨驱动其进展的机制,...
Inflammation is a complex response involving many different cells and signaling molecules, including the secretion of the cytokine IL-17 by activated T cells. IL-17 secretion is restricted to specific subsets of T cells but the receptor for IL-17 is widely expressed throughout the body, including...
et al. Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory. Proc. Natl Acad. Sci. USA 107, 9777–9782 (2010). Article ADS CAS PubMed PubMed Central Google Scholar Gattinoni, L. et al. Wnt signaling arrests effector T cell ...
(TLR)orIL-1/IL-18receptorstodownstreamkinases.InMyD88-dependentTLR4signaling,thefunctionofMyD88isenhancedbyanotherTIRdomain-containingadaptor,Mal/TIRAP,whichbringsMyD88totheplasmamembraneandpromotesitsinteractionwiththecytosolicregionofTLR4.Hence,Malisrecognizedasthe‘‘sortingadaptor’’forMyD88.Inthisstudy,a...
IL-7通过JAK1/STAT3信号通路上调MCP-1促进非小细胞肺癌中MDSCs招募的机制研究 《Scientific Reports》:Interleukin-7 enhances recruitment of MDSCs by regulating MCP-1 via JAK1/STAT3 signaling pathway in non-small cell lung cancer 编辑推荐: 本研究揭示了IL-7通过激活JAK1/STAT3信号通路上调MCP-1表达,...