However, the role of the IL-18/IL-18 receptor-alpha (R alpha) signaling pathway in autoimmune arthritis is unknown. Wild-type (WT) and IL-18R alpha knockout (KO) mice were immunized with bovine type II collagen before the onset of arthritis induced by lipopolysaccharide injection. Disease ...
et al. Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory. Proc. Natl. Acad. Sci. U. S. A. 107, 9777-9782, (2010). 23. Gattinoni, L. et al. Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem ...
Signaling pathway in HEK-Blue™ IL-18 cells HEK-Blue™ IL-18 cellswere engineered from the human embryonic kidney 293 (HEK293) cell line to detectbioactive interleukin-18 (IL-18)by monitoring the activation of the NF-κB and AP-1 pathways. These cells are useful to monitor IL-18 secr...
Our results demonstrated that the IL-18Rα-mediated signaling pathway plays critical roles in CD4+T cells and APCs and responded more quickly to IFN-γ and IL-18 than TLR4 stimulation in the pathogenesis of LPS-induced AKI. 展开 关键词: acute renal failure cytokine CD4+T cells ...
7 showed that the ROS levels were significantly elevated in mouse hearts after radiation exposure and IL-18BP treatment greatly suppressed this radiation-induced ROS, presumably through inhibiting the IL-18-IFN- γ -ROS pathway. ROS are short-lived molecules, which makes them difficult to be ...
Lipopolysaccharide-induced acute kidney injury is dependent on an IL-18 receptor signaling pathway. Int J Mol Sci. 2017;18:2777. Article PubMed Central Google Scholar Nozaki Y, Kinoshita K, Yano T, Asato K, Shiga T, Hino S, et al. Signaling through the interleukin-18 receptor α ...
7 showed that the ROS levels were significantly elevated in mouse hearts after radiation exposure and IL-18BP treatment greatly suppressed this radiation-induced ROS, presumably through inhibiting the IL-18-IFN- γ -ROS pathway. ROS are short-lived molecules, which makes them difficult to be ...
signal transduction natural killer cell activation positive regulation of interferon-gamma production interleukin-18-mediated signaling pathway positive regulation of NF-kappaB import into nucleus T-helper 1 cell differentiation 性能保障 只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述...
The IL-33/ST2 pathway: therapeutic target and novel biomarker. Nat Rev Drug Discov 2008;7:827–40. 26 Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263–5. 27 Gordon D, Finch SJ, Nothnagel M, Ott J. ...
in pathways related to M1 macrophage activation or pathways related to inhibition of M2 macrophages, such as the IL-17 signaling pathway [14], TNF signaling pathway [15], p53 signaling pathway [16], and Toll-like receptor signaling pathway (Fig.2B) [17], We found that the GFPT2 knockdown...