4.2.1 Th17/Treg 比例 辅助性 T 细胞 17(T helper cell 17, Th17) 是一种能够分泌白介素 17(Interleukin 17, IL-17) 的 T 细胞亚群,在自身免疫性疾病和机体防御反应 中具有重要的意义;调节性 T 细胞(Regulatory T cells,Treg)可以通过多种机制来抑制免疫效应细胞 的功能,是肿瘤免疫逃逸的关键因素....
et al. IL-6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines. Int J Cancer. 128, 2803–2814 (2011). 36. Zhou, X. et al. Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of ...
This IL-6/JAK/STAT trajectory is known to be involved in neuropathic pain and synaptic plasticity (Nicolas et al., 2013; Xue et al., 2014). The activated signaling pathway was accompanied by increased sensitivity to thermal and cold stimulations, indicating the aggravated pain behavior. Show ...
upregulation in osteoarthritis (OA) in correlation with the degree of cartilage degradation in vivo. Major peoples OA chondrocytes in vitro react to carbohydrate-inhibitable Gal-4 binding because of the upregulation of pro-degradative/-inflammatory proteins such as interleukin-1β (IL-1β) and ...
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Biomedicines 2022, 10, x FOR PEER REVIEW 3 of 15 Biomedicines 2022, 10, 2799 3 of 15 a new solution using a bifunctional prodrug compound that, when metabolized inside the cells, releases active molecules able to modulate more than one signaling pathway. WWPP11223344((22--ddeeooxyx-y3-,...
and MMPs. Thus, in patients diagnosed with RA, activation of NF-κB signaling pathway results in the transcription of a multitude of responsive genes that contribute to the inflammatory phenotype, including TNF-α, IL-6 and MMPs that, in turn, recruit immune cells to the inflamed pannus. ...
Differential signaling of T cell generation of IL-4 by wild-type and short-deletion variant of type 2 G protein-coupled receptor for vasoactive intestinal ... Vasoactive intestinal peptide (VIP) released from some neurons and T cells affects T cell migration, cytokine generation, and other functi...
Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gamma. J Lipid Res 2000; 41(5): 688-96. Nicholson AC, Han J, Febbraio M, Silversterin RL, Hajjar DP. Role of CD36, the macrophage class B scavenger ...
(B) Pathway-annotated expression heatmap of genes significantly modulated by givastomig/ABL111 (fold change >1.5 and p value<0.05). The gene expression values are normalized as Z-score across six samples (columns). IL, interleukin; NK, natural killer; PBMCs, peripheral blood ...