In clinical studies, recombinant wild-type IL-18 was limited by rapid upregulation of IL-18 binding protein (IL-18BP), which serves as a negative feedback checkpoint of the IL-18 pathway. As its name implies, IL-18BP tightly binds to IL-18, thereby blocking its ability to activate the...
In an effort to identify alternative cytokine pathways for immunotherapy, we found that components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. However, recombinant IL-18 previously did not...
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Lipopolysaccharide-induced acute kidney injury is dependent on an IL-18 receptor signaling pathway. Int J Mol Sci. 2017;18:2777. Article PubMed Central Google Scholar Nozaki Y, Kinoshita K, Yano T, Asato K, Shiga T, Hino S, et al. Signaling through the interleukin-18 receptor α ...
'The treatment of psoriasis remains elusive, underscoring the need for identifying novel disease targets and mechanism-based therapeutic approaches. We recently reported that the PI3K/Akt/mTOR pathway that is frequently deregulated in many malignancies is also clinically relevant for psoriasis. We also ...
Interleukin-10 overexpression improves the function of endothelial progenitor cells stimulated with TNF- through the activation of the STAT3 signaling pathway[J]. Int J Mol Med, 2015,35(2):471-477. DOI: 10.3892/ijmm.2014.2034 . 返回引文位置Google Scholar 百度学术 万方数据...
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pathwayactivation of protein kinase B activityinterferon-gamma productioninterleukin-6 productionpositive regulation of granulocyte macrophage colony-stimulating factor productionpositive regulation of interferon-gamma productionpositive regulation of interleukin-17 productionpositive regulation of natural killer cell ...
匕丨细胞介素18 (IL-18),以前称为干扰素y(IFN-y)诱导 因子，于IL-1家族.能够诱导IFN-7产生、激活自然 杀伤（N K)细胞和毒性T淋巴细胞（C T U、诱导辅 助T细胞（T h),从而在机体抗感染、抗炎以及抗肿 瘤的过程中发挥重要作用。鉴于IL-18在各种肿瘤 中均有不同程度的表达，检测其在血清或者组织中的表达...