Kahraman, D. C., Kahraman, T., & Cetin-Atalay, R. (2019). Targeting PI3K/Akt/mTOR pathway identifies differential expression and functional role of IL8 in liver cancer stem cell enrichment. Molecular Cancer Therapeutics 18, 2146–2157. Sanmamed, ...
参考文献: Waugh DJ, Wilson C. The interleukin-8 pathway in cancer. Clin Cancer Res. 2008;14(21):6735-6741. doi:10.1158/1078-0432.CCR-07-4843. Qin S, LaRosa G, Campbell JJ, et al. Expression of monocyte chemoattractant protein-1 and interleukin-8 recep...
研究成果发表于 Cell Death & Disease 期刊题为“Pivotal role of IL-8 derived from the interaction between osteosarcoma and tumor-associated macrophages in osteosarcoma growth and metastasis via the FAK pathway”。 首先,使用免疫组织化学(IHC)比较原发性 OS 患者和 OS 肺转移性患者部位的 TAM 数量,阐明...
IL-8 (CXCL-8) pathwayimmunotherapypreclinical studiesIL-8 (CXCL-8) is a chemoattractant factor for myeloid leukocytes, that is produced in large quantities by many solid tumors. Levels of IL-8, which can act upon a variety of immune and nonimmune cells, can tell us a lot about tumors, ...
intermediatenegative regulation of G-protein coupled receptor protein signaling pathwaypositive regulation of angiogenesisembryonic digestive tract developmentinduction of positive chemotaxiscellular response to interleukin-1cellular response to tumor necrosis factorregulation of entry of bacterium into host cell...
Additionally, increasing evidence suggests AMPKcan intracellularROS celltypes other thanlung cells [36–42], which makes candidatekinase beingstimulated CS.Whether ROS-sensitiveAMPK signaling pathway CS-inducedlung inflammation stillunknown. We aimed first novelrole NADPHoxidase- dependent ROS-...
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pallidum depends on the pathway downstream of IL-8, rather than on the activation of IL-8 per se. Vascular inflammation characterizes the lesions of secondary and tertiary syphilis and contributes to the degenerative symptoms that accompany the late stages of the disease. T cells cooperate to the...
Hypoxic colorectal cancer cells promote metastasis of normoxic cancer cells depending on IL-8/p65 signaling pathwayColorectal cancerMetastasisTumor heterogeneity is an important feature of malignant tumors, and cell subpopulations may positively interact to facilitate tumor progression. Studies have shown that...
pathways in the proliferation of colon cancer cells. Although the activation of Jak2 has been proven to be involved in IL-8 expression in AGS cells (9), in this study, SN38 significantly inhibited the phosphorylation of Jak2, thus indicating that the Jak2 signaling pathway was not involved in...