功能：IL-5曾补称为T细胞替代因子（Tcellreplacingfactor，TRF），后来发现人类的IL-5对B细胞没有明显...
Overproduction of immunoglobulin E (IgE) and T helper cell type 2 (T2) cytokines, including interleukin 4 (IL-4), IL-5 and IL-13, can result in allergic disorders. Although it is known that IL-4 is critical to the polarization of nave CD4T cells to a T2 phenotype, bothand in many...
Expression of the gene encoding IL-4 by T cells is regulated in two steps — the early stages of T-cell differentiation and the later stage of acute gene expression by differentiated TH2 effector cells. During the first stage, the transcription factor GATA3 (GATA-binding protein 3), which ...
有的实验室称为B细胞刺激因子-1(b cell stimulatingfactor-1,BSF-1)、T细胞生长因子-2(T cell growth factor-2,TCGF-2)。 1986年基因克隆成功,国际统一命名为白细胞介素4(interleukin 4,IL-4)。 白细胞介素4(Interleukin-4,IL4,IL-4)是趋化因子家族的一种细...
IL-4-producing γδ thymocytes in normal mice belong to a distinct subset of γδ T cells characterized by low expression of Thy-1. This γδ thymocyte subset shares a number of phenotypic and functional properties with the NK T cell population. Thy-1dull γδ thymocytes in DBA/2 mice ex...
Here we demonstrate that the burst of IL-4 mRNA, peaking in draining lymph nodes of BALB/c mice 16 hr after infection, occurs within CD4+ T cells that express Vβ4 Vα8 T cell receptors. In contrast to control and Vβ6-deficient BALB/c mice, Vβ4-deficient BALB/c mice were ...
2022年6月8日，斯坦福大学 Christopher Garcia、宾夕法尼亚大学 Carl H. June、加州大学洛杉矶分校 Antoni Ribas、Anusha Kalbasi 等人在 Nature 发表了题为：Potentiating adoptive cell therapy using synthetic IL-9 receptors 的研究论文。该研究表明，人工合成的白细胞介素-9（IL-9）受体可以让过继 T 细胞疗法（...
货号:214-14-20 规格:20ug 价格:1418 货号:214-14-250 规格:250ug 价格:12097 货号:214-14-5 规格:5ug 价格:582 货号:214-14-50 规格:50ug 价格:4143 货号:214-14-500 规格:500ug 价格:17964 产品介绍 产品描述: IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses ...
IL-4 production is associated with low-avidity, poorly cytotoxic T cell induction that contributes to viral immune evasion and the failure of T cell-based vaccines. Yet, the precise mechanisms that regulate IL-4 signalling in T cells remain elusive. Moun
Cutting edge: IL-4 induces functional cell-surface expression of CXCR4 on human T cells IL-4 induces functional cell-surface expression of CXCR4 on human T cells. J. Immunol. 160, 4153 -4157.Jourdan P, Abbal C, Noraz N et al. IL-4 induces functional cell-surface expression of CXCR...