2024年9月25日,相关研究以“A type 2 cytokine Fc–IL-4 revitalizes exhaustedCD8+T cells against cancer”为题在线发表在Nature,EPFL唐力教授、浙江大学药学院郭雨刚研究员以及耶鲁大学樊荣教授为论文的共同通讯作者。值得一提的是,...
功能：IL-5曾补称为T细胞替代因子（Tcellreplacingfactor，TRF），后来发现人类的IL-5对B细胞没有明显...
功能：IL-5曾补称为T细胞替代因子（Tcellreplacingfactor，TRF），后来发现人类的IL-5对B细胞没有明显...
IL-18, an IL-1–like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4T cells, IL-4– and STAT6–dependent fashion. IL-18 and T cell receptor–mediated stimulation could induce nave CD4T cells to develop into IL-4–producing...
IL4 is a pleiotropic cytokine produced by activated T cells. IL4 is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13,which may contribute to many overlapping functions of this cytokine and IL13. STAT6,a signal transducer and activator of transcription,has bee...
Interleukin-4 precursor (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Lymphocyte stimulatory factor 1) (B-cell IGG differentiation factor) (B-cell growth factor 1). Protein Family: Belongs to the IL-4/IL-13 family. 售后服务 相关...
Interleukin-4(IL-4)is a pleiotropic cytokine that induces differentiation of naive helper T cells(Th0 cells)to Th2 cells and produced by mast cells,activated T cells and bone marrow stromal cells.It has many biological roles,including the stimulation of activated B-cell and T-cell proliferation...
1.Feng, B., Bai, Z., Zhou, X. et al. The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer. Nature (2024).网页链接 2.Bai, Z., Feng, B., McClory, S.E. et al. Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission. Nature...
2024年10月30日,来自美国西奈山伊坎医学院的Brian D. Brown和Alessia Baccarini研究团队在Cell上发表题为“Ovarian cancer-derived IL-4 promotes immunotherapy resistance”的文章,用空间功能基因组筛选技术(Perturb-map)重现了肿瘤内异...