Description :IL-4 is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. IL-4 is apotent lymphoid cell growth factor which stimulates the growth and activation of certain B cellsand T cells. IL-4 is important for regulation of T helper subset development. ...
Interleukin (IL)-4 plays a key role in T helper 2 (Th2) cell differentiation favoring humoral immune response. Regulation of IL-4 gene expression, therefore, is critically important for Th2 dependent responses and Th2 dominant disorders. In T cells, IL-4 gene expression is regulated...
I. et al. IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell 62, 457–467 (1990). CAS PubMed Google Scholar Ricci, M., Matucci, A. & Rossi, O. IL-4 as a key factor influencing the development of allergen-specific TH2-like cells...
[22]CHEN L, SHEN Z. Tissue-resident memory T cells and their biological characteristics in the recurrence of inflammatory skin disorders[J]. Cell Mol Immunol, 2020, 17(1):64-75. [23]KAMATA A, KURIHARA Y, FUNAKOSHI T, et...
IL-4 production is associated with low-avidity, poorly cytotoxic T cell induction that contributes to viral immune evasion and the failure of T cell-based vaccines. Yet, the precise mechanisms that regulate IL-4 signalling in T cells remain elusive. Moun
and Homeostasis UNIVERSITY OF MICHIGAN Philip D. King OliverJennifer AnneThe regulation of intracellular signaling is critical to the ability of a T cell to develop, survive, and function in an immune response. In this work, we examined the effect of T cell-specific deletion of the Ras GTPase...
fluidand peripheral blood.theconcentrationsofIFN—YandIL-4in culturemediaweredeterminedby enzyme一1inked immunosorbentassay(ELISA) ReSUlt:ThemeanIFN一、’concentrati onsecretedbYTh cellin peripheral bloodofendometri08iSgroup iS337.63 ±62.94ng/L(X±S,other Saresame),Significantly ...
In contrast, the type II receptor complex formed by either IL-4 or IL-13 is more active during airway hypersensitivity and mucus secretion and is not found in T cells. Product Details Quality Statement BioLegend Cell-Vive™ GMP Recombinant proteins are manufactured and tested in accordance ...
Interleukin (IL)-4 and IL-13 are T helper 2 cytokines whose biological functions are induced through a common IL-4 receptor alpha chain (IL-4Ralpha). CD4(+) T cell-specific IL-4Ralpha-mediated signaling drives susceptibility to Leishmania major infection, but is not essential to host sur...
Consequently, Fc–IL-4 enhances antitumour efficacy of type 1 immunity-centric adoptive T cell transfer or immune checkpoint blockade therapies and induces durable remission across several syngeneic and xenograft tumour models. Mechanistically, we discovered that Fc–IL-4 signals through both signal ...