IL-18 and T cell receptor–mediated stimulation could induce nave CD4T cells to develop into IL-4–producing cells. Thus, caspase-1 and IL-18 may be critical in regulation of IgE production, providing a potential therapeutic target for allergic disorders.Tomohiro Yoshimoto...
Expression of the gene encoding IL-4 by T cells is regulated in two steps — the early stages of T-cell differentiation and the later stage of acute gene expression by differentiated TH2 effector cells. During the first stage, the transcription factor GATA3 (GATA-binding protein 3), which ...
德国莱布尼茨免疫治疗研究所Luca Gattinoni教授和美国国家心肺血液研究所Warren J. Leonard教授研究团队于2024年8月9在Signal Transduction and Targeted Therapy发表题为“LIM-domain-only 4 (LMO4) enhances CD8+T-cell stemness and...
504124PerCP/Cyanine5.5 anti-mouse IL-4 AntibodyPerCP/Cyanine5.5 抗小鼠 IL-4 抗体100 μg￥5,700.00 Description :IL-4 is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. IL-4 is apotent lymphoid cell growth factor which stimulates the growth and activation of...
而IL2属于淋巴细胞活素(lymphokine),以前曾以胸腺细胞刺激因子(thymocyte stimulating factor)、T细胞生长因子(T cell growth factor)等六种名称称之[1]。 根据细胞因子的结构同源性可将成员分为几个蛋白质家族,如IL-1家族、IL-6家族、IL-10家族、肿瘤坏死因子家族和造血因子家族等。IL穿插归类为其中,如下表[5...
Lidia Yshii et al, Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation, Nat Immunol . 2022 May 26 Schroeter CB, Huntemann N, Bock S...
22. Avanzi MP, Yeku O, Li X, et al. Engineered TumorTargeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the EndogenousImmune System. Cell Rep 2018;23:2130-41. 23. Canna SW, de Jesus AA, Gouni S, et al. An activating NLRC4 inflammasome mutati...
揭秘CD8 T 细胞免疫调控新机制:旁分泌 IL-2 信号主导的独特启动阶段 《SCIENCE》:A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals 编辑推荐: 为探究激活的 T 细胞脱离树突状细胞(DCs)后如何接收分化所需的旁分泌信号,研究人员开展了关于 T 细胞启动阶段的研究。
Yang ZZ, Grote DM, Ziesmer SC, Niki T, Hirashima M, Novak AJ, Witzig TE, Ansell SM (2012) IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma. J Clin Invest 122(4):1271–1282. ...
2022年11月28日,牛津大学研究团队在Nature Communications(IF=17.694)杂志上发表题为“Low-dose IL-2 reduces IL-21+T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes”的研究论文。作者对13位试验对象进行了间隔IL-2给药,分选了Day 0,Day 27和Day 55三个不同时间点给药后...