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IL-2 receptor Beta chain in T cell activation pathway.Min, ChenJudy, ChoHongyu, Zhao
Here, we show immunosuppressive property of streptavidin on T cell activation and proliferation. Upon CD3 and CD28 stimulation, CD4+ T cells produce interleukin 2 (IL-2) and express IL-2 receptor α chain (CD25). Addition of streptavidin in T cell culture suppressed IL-2 synthesis and CD25 ...
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2021年12月22日,Science Translational Medicine上背靠背发表两篇题为An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CAR T cells and clearance of bulky lymphoma和A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine...
2021年12月22日，Science Translational Medicine上背靠背发表两篇题为An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CAR T cells and clearance of bulky lymphoma和A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a ...
IL-2是一种可扩增T细胞和NK细胞的多效细胞因子。IL-2同时可以激活免疫抑制性调节T细胞(Regulatory T cells,Treg)、诱导效应T细胞死亡(Activation induced cell death,AICD)、刺激血管内皮细胞,产生严重的毒副作用,因而未被应用于临床。 ...
考虑到【Activation of Naive and Memory T Cells by IL-15.】之前的工作,这些条件导致CD8+记忆T细胞更高的生长应该并不足为奇,其中IL-15提供了显着的生长促进。即使“002”条件确实导致了生长速度的降低,但当单独与IL-7或IL-2配对时...
Corneal endothelial cells block T cell proliferation, but not T cell activation or responsiveness to exogenous IL-2 We previously reported that Ia+ monolayers of LEW rat corneal endothelial (CE) cells were unable to stimulate proliferation of MHC compatible T cell lines ... H Kawashima,DS Gregers...
[97]. Early fatal autoimmune disease otherwise observed in mice with Treg-specific IL-2R deficiency can be rescued by constitutive STAT5 signalling; however, the mice still succumbed at a later age from uncontrolled CD8 T cell activation and expansion. This demonstrated that IL-2 consumption via...