2021年12月22日，Science Translational Medicine上背靠背发表两篇题为An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CAR T cells and clearance of bulky lymphoma和A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murin...
结论：更普遍地设计位点特异性的细胞因子聚乙二醇化能改善其治疗性能，用于治疗自身免疫性疾病。出处：Zhang B, et al. Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells. Nat Biomed Eng. 2021 Sep 27. doi: 10.1038/s41551-021-00797-...
2022年7月5日，Moderna公司的Eric Huang等人在Nature Communications期刊发表了题为：Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein（使用脂质封装的编码长效 IL-2 突变蛋白的 mRNA 可选择性激活和扩增调节性 T 细胞）的研究论文。图1 ...
A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals Katarzyna Jobin et al.Science. 2025 T cell priming, the initial activation of T cells by dendritic cells (DCs), is essential...
4. Emmerich J, Bauer M, Semana M, Jayaraman B, Vivona S, McCauley S, et al. Abstract 1744: STK-012, an alpha/beta selective IL-2 mutein for the activation of the antigen-activated T cells in solid tumor.Cance...
2022年7月5日,mRNA明星企业Moderna在 Nature Communications 杂志发表研究成果:“Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein”。研究基于mRNA-纳米脂质体(LNP, Lipid nanoparticles)平台,合成编码IL-2突变体的mRNA,可在小鼠或非人灵长...
Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain ...
-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunityIntratumoral regulatory T (T) cell abundance associates with diminished antitumor immunity and poor prognosis in human cancers. Recent work demonstrates that CD25, the high-affinity receptor...
Satoh M, Toma H, Sugahara K, Etoh K, Shiroma Y, Kiyuna S, et al. Involvement of IL-2/IL-2R system activation by parasite antigen in polyclonal expansion of CD4(+)25(+) HTLV-I-infected T-cells in human carriers of both HTLV-I and S. stercoralis. Oncogene 2002; 21:2466-2475....
The activity of IL-2Rβ/IL-2Rγ VHH dimers on primary T cells was also examined. Similar to NK cells, IL-2Rβ/IL-2Rγ VHH dimers induced pSTAT5 phosphorylation, proliferation and IFN-γ production by CD4 positive and CD8 positive T cell blasts generated after CD3/CD28 activation of ...