These results indicate that activation of T cells with bryostatin should be carried out under protection of exogenous IL-2 to ensure survival and expansion of T cells that may exhibit anti-tumor activity.Ferdynand J. Kos and David L. Cornell and Anne B. Lipke and Laura J. Graham and Harry...
IL-12 has been shown to stimulate the proliferation of activated T cells and natural killer (NK) cells (Gately et al., 1991) and to cause interferon- 纬 (IFN- 纬 ) production (Kobayashi et al., 1989; Chan et al., 1991) and enhanced NK lytic activity (Kobayashi et al., 1989; ...
结论：更普遍地设计位点特异性的细胞因子聚乙二醇化能改善其治疗性能，用于治疗自身免疫性疾病。出处：Zhang B, et al. Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells. Nat Biomed Eng. 2021 Sep 27. doi: 10.1038/s41551-021-00797-...
结论:更普遍地设计位点特异性的细胞因子聚乙二醇化能改善其治疗性能,用于治疗自身免疫性疾病。 出处:Zhang B, et al. Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells. Nat Biomed Eng. 2021 Sep 27. doi: 10.1038/s41551-021-00797-8....
编码长效IL-2突变蛋白的mRNA可选择性激活和扩增调节性T细胞 2022年7月5日，Moderna公司的Eric Huang等人在Nature Communications期刊发表了题为：Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein（使用脂质封装的编码长效 IL-2 突变蛋白的 ...
2022年7月5日,Moderna公司的Eric Huang等人在Nature Communications期刊发表了题为:Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein(使用脂质封装的编码长效 IL-2 突变蛋白的 mRNA 可选择性激活和扩增调节性 T 细胞)的研究论文。
2022年7月5日,Moderna公司的Eric Huang等人在Nature Communications期刊发表了题为:Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein(使用脂质封装的编码长效 IL-2 突变蛋白的 mRNA 可选择性激活和扩增调节性 T 细胞)的研究论文。
结论:更普遍地设计位点特异性的细胞因子聚乙二醇化能改善其治疗性能,用于治疗自身免疫性疾病。 出处:Zhang B, et al. Site-specific PEGylation of interleukin-2 enhancesimmunosuppressionvia the sustainedactivationof regulatory T cells. Nat Biomed Eng. 2021 Sep 27. doi: 10.1038/s41551-021-00797-8. Epub...
摘要: Regulatory T cells are in the focus of research on autoimmunity. However, recent findings suggest that pro-inflammatory T(H)1 cells themselves exert important immunoregulatory functions. This physiological self-limiting mechanism holds great promise for therapeutic interventions....
2021年12月22日，Science Translational Medicine上背靠背发表两篇题为An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CAR T cells and clearance of bulky lymphoma和A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a ...