CD8+ T cellsIL-10PD-1T cell activationT cell exhaustion\n Trypanosoma cruzi\nIL-10 is a pleiotropic cytokine with immunoregulatory functions affecting various cell types. In a model of experimental infection with the protozoan Trypanosoma cruzi (T. cruzi), we found increased morbidity and lower ...
Effects of IL-10 on endothelium-dependent T cell activation have not been investigated in detail. We confirm expression of the IL-10 receptor and effective signaling via STAT-3 in human umbilical vein endothelial cells (HUVEC). In CD4 T cell cocultures with HUVEC, pretreatment of endothelial ...
GM-C30308 ：H_IL10RA CHO-K1 Cell Line+GM-C30308+Anti-H_IL10RA hIgG1 Antibody+流式验证结果 参考资料：（1）DOI：10.1615/CritRevImmunol.v32.i1.30 （2）Williams LM, Ricchetti G, Sarma U, et al. (2004) Interleukin-10 suppression of myeloid cell activation--a continuing puzzle. Immun...
receptors. We then tested if IL-10 could impact costimulation-independent T cell activation (recognized to afflict the efficacy of CoB). In vitro experiments clearly showed that IL-10 neutralizes the poorly investigated effect of TLR-mediated costimulati...
Cottrez F, Groux H (2001) Regulation of TGF-beta response during T cell activation is modulated by IL-10. J Immunol 167: 773-778... F Cottrez,H Groux - 《Journal of Immunology》 被引量: 322发表: 2001年 Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β ...
Role of Il10 and Il12 in Il2 Induced T-Cell ActivationEuropean Society for Paediatric Haematology and Immunology Abstractdoi:10.1203/00006450-199905010-00107Kim, Y MVerheyen, JBanning, UBonig, HBurdach, SKorholz, DPediatric Research
Interleukin-10 (IL-10) is a homodimeric protein that is produced by macrophages, dendritic cells and helper T cells in response to multiple stimuli1–3. Actions of IL-10 on immune cells in vitro include the inhibition of both macrophage and T cell activation and of pro-inflammatory cytokine...
In humans IL-10 is produced by activated CD8(+) peripheral blood T-cells, by T-helper CD4 (+) T-cell clones (resembling Th0 , Th1 , and Th2 ) after both antigen-specific and polyclonal activation, by B-cell lymphomas, and by monocytes following cell activation by bacterial ...
1.Williams LM, Ricchetti G, Sarma U, et al. (2004) Interleukin-10 suppression of myeloid cell activation--a continuing puzzle. Immunology 113(3):281-92. Review. 2.Hu X, Chen J, Wang L, Ivashkiv LB (2007) Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in...
Addition of IL-10 reduced expression of activation antigens and the stimulatory ability of LPLs from either IBD patients or from these cell lines. In summary, LPLs from active IBD, but not from disease controls, express activation antigens that stimulate nave T cells, a process that is ...