IL-2 and long- term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells. Oncogene 2000; 19: 2086-2097.Rameil, P. Lecine, J. Ghysdael, F. Gouilleux, B. Imbert, J. (2000). IL-2 and long-term T cell activation ...
Conjugated to a single chain anti-CD7 variable fragment (scFvCD7), streptavidin was directly delivered to T cells and showed substantially more profound suppressive effect on T cell activation. These results suggest that streptavidin could potentially be used as a novel immunomodulator. 展开 关键词: ...
近日,来自美国Asher Biotherapeutics公司的Ivana M. Djuretic团队在Cancer Discovery杂志上发表了一篇题为IL-2 targeted to CD8+ T cells promotes robust effector T cell responses and potent antitumor immunity的文章,他们开发了一种CD8...
The transcription factor NFATc2 controls IL-6–dependent T cell activation in experimental colitis In this study, we have identified a crucial regulatory role of the transcription factor NFATc2 in T cell鈥揹ependent experimental colitis. Similar to ... B Weigmann,HA Lehr,G Yancopoulos,... -...
2021年12月22日，Science Translational Medicine上背靠背发表两篇题为An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CAR T cells and clearance of bulky lymphoma和A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a ...
Lymphocyte ActivationObjective Interleukin (IL)-10 is an immunosuppressive cytokine produced by many cell types, including T cells. We previously reported that a novel type of regulatory T (Treg) cells, termed HOZOT, which possesses a FOXP3+CD4+CD8+CD25+ phenotype and dual suppressor/cytotoxic ...
T cell activation by antigen/MHC induces the expression of several genes critical to the immune response, including interleukin-2. T cells from mice defici... Shapiro,S V. - 《Journal of Experimental Medicine》 被引量: 174发表: 1996年 The coreceptor CD2 uses plasma membrane microdomains to tr...
(IL-2) acts as an environmental cue to induce CD8+T cell exhaustion within tumor microenvironments. We find that a continuously high level of IL-2 leads to the persistent activation of STAT5 in CD8+T cells, which in turn induces strong expression of tryptophan hydroxylase 1, thus catalyzing...
Given the powerful immunosuppressive properties of Treg, it is clearly suboptimal to reduce this population whilst aiming to suppress immune activation. Consequently, strategies that restrict the effects of costimulation blockade to the conventional T cell compartment, while sparing Treg, would be highly ...
B图中 横坐标ortho表示ortho IL-2R β的CD8+ T细胞,wild-type表示未经改装的CD8+ T细胞。经过IL-2刺激之后,过继的CD8+ T能维持在较高水平。 评价IL-2对机体免疫功能的影响,可以检测受体小鼠脾脏重量以及脾脏内CD8+ memory phenotype T cell、CD4+ Treg、和NK细胞数量的变化。CD8+ MP( CD44+CD62L+)、CD4...