IL-2T cell activationTumor immunotherapyPharmacologic agents such as bryostatin 1 (bryostatin) can regulate cell activation, growth, and differentiation by modulating the activities of protein kinase C isoenzymes. Inhibition of growth of tumor cells and activation of T lymphocytes in vitro are the ...
Activated dendritic cells (DCs) express CD25 on their cell surface for binding either T cell- or DC-derived IL-2, in order to present IL-2 intransto adjacent effector T cells. This mechanism presumably operates very early during T cell stimulation, before the responding T cells start to expr...
Interleukin-2 is essential for CD4+CD25+ regulatory T cell function. Constitutive expression of CD25, the IL-2 receptor -chain, defines a distinct population of CD4+ T cells (Treg) with suppressive activity in vitro and in v... MDL Rosa,S Rutz,H Dorninger,... - 《European Journal of ...
Role for T cells, IL-2 and IL-6 in the IL-4-dependent in vitro human IgE syn- thesis. Immunology 1989;68:300-6.Noncognate contactdependent B cell activation can promote IL-4-dependent in vitro human IgE synthesis - Parronchi, Tiri, et al. - 1990...
The regulatory, inflammatory, and T cell programming roles of interleukin-2 (IL-2) Signaling through IL-2 induces the activation of pathways that lead to the proliferation, survival and cytokine production of effector T cells. However, th... LCSE Gershwin - 《Journal of Autoimmunity》 被引量:...
We have previously shown that expression of HMGI antisense RNA in Jurkat T cells inhibits the activity of the IL-2 promoter. Here we have investigated the role of HMGI(Y) in controlling IL-2 promoter-reporter constructs as well as the endogenous IL-2 gene in both Jurkat T cells and ...
In some cell types, TPL2 contributes to the optimal activation of p38 MAPK and JNK, specifically in response to genotoxic stress or inflammatory stimuli such as TNFα or IL-1β41,42,43,44. TPL2 crosstalks to the NF-κB pathway37. In its inactive state, TPL2 protein is stabilized and ...
The IL-33/ST2 axis has been implicated in various Th2 responses. Its role in CD8+ T-cell-mediated immune response is, however, not known. Here we... Q Yang,L Gang,Y Zhu,... - 《European Journal of Immunology》 被引量: 262发表: 2011年 Disordered IL-33/ST2 Activation in Decidualiz...
(asialo GM-1, shown; NK1.1, not shown) and a T-cell activation marker (CD69) on CD8 T cells were analyzed to assess the activation status of these cells. As shown in Figure 2, there was no meaningful induction of these markers on CD8 T cells during the tumor development, suggesting...
Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue damage. In this Review, we discuss the role of T cells in the onset and progression of age-associated conditions, fo...