IL-2 Stimulation of Regulatory TCells: A Stochastic and Algorithmic ApproachRegulatoryde la Higuera, Luis TcellsLópez-García, Martín expressLythe, Grant IL-2 receptor (IL-2R) complexesMolina-París, Carmen on their surface, but do not produ...
Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells. Proc. Natl Acad. Sci. USA 107, 11906–11911 (2010). Article CAS PubMed PubMed Central Google Scholar Spangler, J. B. et al. Antibodies to interleukin-2 elicit selective T cell ...
More recently, the mechanisms by which IL-2 regulates CD4+ T cell differentiation and function have been elucidated. IL-2 also regulates the effector and memory responses of CD8+ T cells, and the loss of IL-2 or responsiveness to IL-2 at least in part explains the exhausted phenotype that...
IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. IL-2/IL-2R signaling is required for T-cell proliferation and other ...
In contrast to its well established Sos-mediated Ras activation mechanism in IL-2-stimulated T cells, the identity of the Rac GEF responsible for Rac activation in IL-2-stimulated signaling has not been determined. Here we show that subsequent to IL-2 stimulation αPIX-Rho-GEF mediates PYGM ...
The effects of Proleukin, IgG-IL-2, and IgG-(IL-2)2 on the induction of pSTAT5a were assessed in human CD4+ Treg subsets, naïve and memory conventional CD4+ T cells, memory conventional CD8+ T cells, CD45RA+ CD8+ T cells, NKT cells and NK cells. IgG-IL-2 and IgG-(IL-2)...
Interleukin-2 (IL-2), commonly called T cell growth factor, is produced by T lymphocytes in response to antigenic stimulation and is crucial for regulatory T cells expansion. Previous studies have demonstrated that defects in the IL-2 receptor and its downstream signaling pathways are closely link...
Gene therapy using tumor cells genetically modified to express cytokines or surface determinants is a promising technique for stimulating antitumor responses. A potential pitfall in its application to cancer, however, is that some patients' T cells are immune suppressed and may resist stimulation by ...
IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. It is expressed by CD4+and CD8+T cells, γδ T cells, B cells, dendritic cells, and eosinophils. IL-2/IL-2R signaling is required for T cell proliferation and other fund...
IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation o...