T-cell activation is a critical driver of immune responses. The CD28 costimulation is an essential regulator of CD4 T-cell responses, however, its relative importance in naive and memory T cells is not fully understood. Using different model systems, we observe that human memory T cells are mo...
Angina pectorisUnstable anginaMyocardial infarctionMast cell accumulation and activation have been demonstrated in the vulnerable shoulder regions of atherosclerotic ... H Kervinen,M Kaartinen,H M?Kynen,... - 《International Journal of Cardiology》 ...
HER2-XPAT protein and unmasked HER2-TCE promoted similar T-cell activation in the tumor microenvironment (TME), indicated by increased expression of activation marker CD25 on both helper and cytotoxic T cells (Fig. 3c). T cells were not activated in peripheral blood where human HER2 is not ...
T cell activation via the αβ-T cell receptor (TCR complex) is required for in vitro expansion. Treatment of T cells with monoclonal anti-CD3 antibodies and anti-CD28 antibodies provide a co-stimulatory signal that engages the TCR...
The objective of this study is to compare the effects of true μg and sμg on the expression of key early T-cell activation genes in mouse splenocytes from spaceflight and ground animals. For the first time, we compared all three conditions of microgravity spaceflight, RPM, and RWV ...
Increased expression of T cell activation markers (CD25, CD26, CD40L and CD69) in atherectomy specimens of patients with unstable angina and acute myocardi... et al.Increased expression of T cell activation markers (CD25,CD26,CD40L and CD69) inatherectomy specimens of patients with unstable...
Since Helios expression is associated with T cell activation and cellular division, regardless of the cell subset involved, it does not appear suitable as a marker to distinguish natural and induced Treg cells. 展开 关键词: Animals Humans Mice T-Lymphocytes Cells, Cultured Transcription Factors DNA...
4. T cell activation requires the orchestration of signaling pathways and metabolic reprogramming Upon antigen recognition, CD4+ and CD8+ naïve T cells become highly proliferative and differentiate into Teff cells that exert their function as CD4+ T helper (Th) cells, such as Th1, Th2 or Th1...
describe a ring of focal adhesion molecules that surrounds T cell receptor microclusters and is essential for early T cell activation. The immunological synapse (IS) formed at the interface between T cells and antigen-presenting cells represents a hallmark of initiation of acquired immunity. T cell...
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