Cell biology of T cell activation and differentiation. Int Rev Cytol, 2006, 250:217-274. 45 Schmitt AB, Breuer S, Liman J, et al. Identification of regeneration-associated genes after central and peripheral nerve injury in the adult rat. BMC Neurosci 2003, 4: 8.Santana MA, Esquivel-...
4. T cell activation requires the orchestration of signaling pathways and metabolic reprogramming 5. Memory T cells—remembering metabolic pathways 6. Regulatory T cells—against the (glycolytic) flow 7. Metabolism underlying T cell differentiation—key metabolic checkpoints and pathways 8. Future perspe...
Targeting T cell metabolism to regulate T cell activation, differentiation and function in disease It is becoming increasingly clear that metabolic reprogramming plays a critical role in T cell activation, differentiation and function. To this end, cellular metabolism not only meets the energetic ...
Activation requirements for the induction of CD4+CD25+ Tcell suppressor function The in vivo differentiation/survival of CD4+CD25+ Tsuppressor cells is dependent on IL-2 and CD28-mediated costimulatory signals. To determine the cytokine... AngelaM. Thornton,CiriacoA. Piccirillo,EthanM. Shevach -...
N. et al. Cytochrome c oxidase activity is a metabolic checkpoint that regulates cell fate decisions during T cell activation and differentiation. Cell Metab. 25, 1254–1268 (2017). Article CAS PubMed PubMed Central Google Scholar Macintyre, A. N. et al. The glucose transporter Glut1 is...
Most of them take advantage of T cell biology, primarily targeting the engagement of the T cell receptor (TCR) that initiates sufficient intracellular signal transduction and drives productive activation, proliferation, and differentiation1. In turn, activation of T cells serves a plethora of purposes...
Differentiation and Activation Surface Marker Associated with T Cell Thymic Shared Antigen-2: A Novel Cell R Boyd,M Malin,B Classon,... 被引量: 0发表: 1999年 Antigenic Heterogeneity of Vascular Endothelium The antigenic status of vascular endothelium from different sites of the normal adult and...
Learning module part 2covers T cell isolation andin vitroactivation, assessment of T cell activation, proliferation, and differentiation by these methods: Flow cytometric analysis Enzyme-linked immunosorbent assay...
mTOR signaling in CD8+ T-cell activation andmemory differentiation CD8+T细胞对获得性免疫至关重要。它们在最初的反应中清除病原体,形成记忆细胞,提供即时和强大的保护,防止病原体再次攻击。CD8+T细胞对急性感染的反应动力学可简化为三个...
activation by decreasing expression of MHC-I molecules to prevent the activating signal or through directing the T-cell differentiation or activity[12–15]. The latter is a diverse method involving the interaction of cells in thetumor microenvironmentand can function by increasing infiltration of...