Understanding of the differentiation and maturation of T cells has been greatly enhanced by several technical . Certainly, the most important of these has been the rapid expansion in the availability of monoclonal antibodies to identify surface markers on T cells. Utilization of these antibodies has ...
T Cell Differentiation A naive lymphocyte is not a functional immune cell. To exert its functions, T cells differentiate into two major populations of effector cells: type one and type two. Type one cells produce IFN‐γ and coordinate systemic cell‐mediated immune responses, controlled by cytoto...
N. et al. Cytochrome c oxidase activity is a metabolic checkpoint that regulates cell fate decisions during T cell activation and differentiation. Cell Metab. 25, 1254–1268 (2017). Article CAS PubMed PubMed Central Google Scholar Macintyre, A. N. et al. The glucose transporter Glut1 is...
激动选择后的非经典 T 细胞主要可分为3类,分别是FOXP3+调节性T细胞(regulatory cell,Treg)、自然杀伤性T 细胞(natural killer T cell,NKT)和 TCRαβ+CD8αα+T 细胞[16, 18]。不识别自身抗原肽的 T 细胞进一步分化为成熟的 CD4+或 CD8+SP ...
D. Targeting T cell metabolism to regulate T cell activation, differentiation and function in disease. Curr. Opin. Immunol. 46, 82–88 (2017). CAS PubMed PubMed Central Google Scholar McLane, L. M., Abdel-Hakeem, M. S. & Wherry, E. J. CD8 T cell exhaustion during chronic viral ...
Runt domain-related transcription factor 3 (Runx3) is considered a key regulator in promoting CD8 + T cell maturation [127], cytotoxic T lymphocyte (CTL) differentiation [128], and the formation of tissue-resident memory T cells (Trm) [129]. A study suggested that overexpression of Runx...
Turning cold tumors into hot tumors by improving T-cell infiltration 通过改善 T 细胞浸润将冷肿瘤转变为热肿瘤 摘要 【1】以免疫检查点抑制剂(ICIs)为代表的免疫疗法极大地提高了恶性肿瘤治疗的临床疗效。ICI 介导的抗肿瘤反应依赖于能够识别和杀死肿瘤细胞...
Regulation on activation, normal T cell expressed and secreted VV: Vaccinia virus HCV: Hepatitis C virus MCMV: Murine cytomegalovirus ISGs: IFN-stimulated genes HSV-1: Herpes simplex virus type 1 TG: Trigeminal ganglion NO: Nitric oxide iNOs: Inducible nitric oxide synthase VSV: Ve...
was expressed on activated/memory subsets of T cells,and T cells from BAFF-R mutant A/WySnJ mice failed to respond to BAFF costimulation.Thus,BAFF-R is important not only for splenic B cell maturation,but is the major mediator of BAFF-dependent costimulatory responses in peripheral B and T...
γδ T cells are a distinct subset of unconventional T cells, which link innate and adaptive immunity by secreting cytokines and interacting with other immune cells, thereby modulating immune responses. As the first line of host defense, γδ T cells are essential for mucosal homeostasis and immu...