The application of chimeric antigen receptor (CAR) T cells in the management of hematological malignancies has emerged as a noteworthy therapeutic breakthrough. Nevertheless, the utilization and effectiveness of CAR-T cell therapy in solid tumors are sti
TCR–CD8αβ+CAR T cells that perform similarly to CD8αβ+CAR T cells from peripheral blood, achieving effective tumour control on systemic administration in a mouse model of leukaemia and without causing graft-versus-host disease. Driving T-cell maturation in TiPS in the absence of a TCR ...
B-cell maturation antigen (BCMA) is expressed in most cases of MM. We conducted the first-in-humans clinical trial of chimeric antigen receptor (CAR) T cells targeting BCMA. T cells expressing the CAR used in this work (CAR-BCMA) specifically recognized BCMA-expressing cells. Twelve ...
Inflammasome activation triggers the release of active interleukin 1β (IL-1β). Li and colleagues show that TH17 cells can release IL-1β upon T cell antigen receptor and ATP stimulation via an ASC–NLPR3–caspase-8 axis, thereby contributing to neuroin
Chaput N, Darrasse-Jeze G, Bergot AS, Cordier C, Ngo-Abdalla S, Klatzmann D, Azogui O (2007) Regulatory T cells prevent CD8 T cell maturation by inhibiting CD4 Th cells at tumor sites. J Immunol 179(8):4969–4978 PubMed CAS Google Scholar Antony PA, Paulos CM, Ahmadzadeh M, Ak...
The importance of CXCR4 in T-ALL pathogenesis would not have been anticipated on the basis of its role in normal T cell maturation. T cell development is profoundly dependent, at different stages, on signaling through Notch1, pre- T cell receptor (TCR)/TCR, and interleukin-7 receptor (IL...
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人T 细胞高效扩增试剂盒 Human T cell robust expansion kit,2L/套,大包装可定制, 产品货源充足,质量保证,下单即可发货,部分产品需提前订购,下单后1-2个工作日内 更多详细 人DC 细胞体外快速成熟试剂盒 Human Dendritic Cell Rapid Maturation Kit 人DC 细胞体外快速成熟试剂盒 Human Dendritic Cell Rapid Matur...
J. et al. Production of IL-10 by CD4+ regulatory T cells during the resolution of infection promotes the maturation of memory CD8+ T cells. Nat. Immunol. 16, 871–879 (2015). Article CAS PubMed PubMed Central Google Scholar Gerriets, V. A. et al. Foxp3 and Toll-like receptor ...