T cell development in the thymus is controlled by a multistep process. The NF-κB pathway regulates T cell development as well as T cell activation at multiple differentiation stages. The linear ubiquitin chain assembly complex (LUBAC) is composed of Sharpin, HOIL-1L and HOIP, and it is cru...
T-cell activationT-cell maturationT-cell signal transductionthymusGerald B. PierHoward CeriChris ModyMichael PrestonJohn Wiley & Sons, LtdPier GB, Geri H, Mody C, Preston M. T-cell maturation and activation. Washington, DC: ASM Press; 2004....
The application of chimeric antigen receptor (CAR) T cells in the management of hematological malignancies has emerged as a noteworthy therapeutic breakthrough. Nevertheless, the utilization and effectiveness of CAR-T cell therapy in solid tumors are sti
One of the earliest maturation steps in cardiomyocytes (CMs) is the sarcomere protein isoform switch between TNNI1 and TNNI3 (fetal and neonatal/adult troponin I). Here, we generate human induced pluripotent stem cells (hiPSCs) carrying a TNNI1EmGFP and
CD19 is seen to be expressed at an earlier stage in the maturation process of B cells, which led to its selection as a potential target. The presence of B cellaplasiawas expected as a potential adverse consequence due to its prevalence in normal B cells. However, this occurrence is commonl...
This difficulty stems from the inability of existing methods to not only mimic the events of embryonic hematopoiesis but also to enable the complex selection and maturation steps of T cell development that occur in the post-natal thymus (Kennedy et al., 2012). T cells develop as bone marrow-...
我们对“冷肿瘤”潜在机制的理解进行了批判性审查【critical review】,包括 T 细胞启动受损【including impaired T-cell priming】和 T 细胞归巢到肿瘤床的缺陷。具有显著 T 细胞浸润的“热肿瘤”与更好的 ICI 疗效相关。在这篇综述中,我们总结了多种促进“...
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Autophagosomes must undergo a series of maturation steps, in part by fusing with endocytic vesicles, including early and late endosomes and multivesicular bodies (MVBs) [26, 36, 37]. Proper maturation of the autophagosome requires an intact endocytic trafficking pathway, components of the endosomal ...