但是这些标签总是静止的,而T细胞是在免疫过程中定义的,他们的名字很清楚:Naïve / Memory Cells / T Helper Cell / Antigen-Specific T Cell Exhaustion / Regulatory T Cells /γδ T Cells,虽然也有叫做CD4T / CD8T 的。细胞的名称就像代码中的变量名一样,应该是有意义的,而不只是个标签。
Epigenetic modifying proteins can act differentially within CD8+ T cell differentiation subsets to regulate gene expression, and altering the activities of these enzymes can have profound effects on T cell differentiation and function. T cell exhaustion represents a state of arrested differentiation. Rever...
Cell cycle proteins are critical regulators of proliferation in dividing cells. Paradoxically, accumulating evidence supports the view that core components... EBE Becker,A Bonni - 《Seminars in Cell & Developmental Biology》 被引量: 88发表: 2005年 Trans-Differentiation And Re-Differentiation Of Somati...
T Cell Differentiation A naive lymphocyte is not a functional immune cell. To exert its functions, T cells differentiate into two major populations of effector cells: type one and type two. Type one cells produce IFN‐γ and coordinate systemic cell‐mediated immune responses, controlled by cytoto...
A signalling system comprised of highly conserved transmembrane receptors that regulate cell fate choice in the development of many cell lineages and are thus crucial for the regulation of embryonic differentiation and development. Unusually among signalling systems, the cytoplasmic domain of each Notch tr...
The differentiation pattern of splenic T-cell populations in germ- and pathogen-free nu/nu mice, as compared to nu/+ littermates, is characterized by two abnormal features: (i) the expression of TL determinants on peripheral T cells and (ii) the delayed onset of their differentiation from ...
cross-species sequence analyses, we have identified three conserved noncoding sequences upstream of the Ifng transcriptional start site, one of which (CNS−22) contains a cluster of consensus binding sequences for transcription factors known to function in T cell development and differentiation. Prom...
Their efforts failed to result in a robust population of keratinocytes on the three-dimensional matrix and they failed to observe T cell differentiation. First and foremost, we agree that if there is not a viable robust population of keratinocytes, T cell differentiation will not occur. We have...
[Part 1: Biological Sciences] || Development of a Human T-Cell Hybridoma Secreting Separate B-Cell Growth and Differentiation Factors JL Butler,FAS Fauci - 《Proceedings of the National Academy of Sciences of the United States of America》...
These T helper cell subsets can be differentiated from nave T cells. In addition, recent findings indicate that some T helper cell subsets can emerge from other T helper cells, suggesting a certain degree of plastiticy. Here we report basic aspects of T helper cell differentiation and function...