A schematic diagram for the dependence of T cell differentiation on intracellular phosphorylation signaling.Ildar I. SadreevMichael Z. Q. ChenGavin I. WelshYoshinori UmezawaNikolay V. KotovNajl V. Valeyev
Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade can reinvigorate TEX cells, but reinvigoration is not durable. A major unanswere
Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057–1061 (2003). Article CAS PubMed Google Scholar Gavin, M. A. et al. Foxp3-dependent programme of regulatory T cell differentiation. Nature 445, 771–775 (2007). Article CAS PubMed Google Scholar...
T cell receptor gamma and delta rearrangements in hematologic malignancies; Relationship to lymphoid differentiation J Clin Invest, 84 (1989), p. 506 View in ScopusGoogle Scholar 18. Macintyre E, d’Auriol L, Amesland F, Loiseau P, Chen Z, Boumsell L, Galibert F, Sigaux F Analysis of ...
A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflamma- tion. Nat Immunol. 2001;2:45–50. 27. Lundy SK, Lerman SP, Boros DL. Soluble egg antigen-stimulated T helper lymphocyte apoptosis and evidence for cell death mediated by FasL(+) T ...
During vascular system and floral organ differentiation, the parsley 4CL-1 gene is expressed in a restricted set of tissues and cell types where 4CL ... KD Hauffe,SP Lee,R Subramaniam,... - 《Plant Journal》 被引量: 340发表: 1993年 ...
Many circRNAs are involved in cell proliferation, differentiation, apoptosis, invasion, stemness and resistance to therapy of HCC [16,17,18]. For instance, Huang et al. indicated that circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in HCC via the miR-30-5p/snail/...
cell subset. Moreover, we observed evidence of a progressive increase in the amount of differentiation from naïve T cells, to TCM, and finally to TEMand TEMRAmemory populations. One set of genes that were upregulated, included those that reflected changes in metabolic capacity of the MTC ...
The efficacy of adoptive T-cell therapies largely depends on the generation of T-cell populations that provide rapid effector function and long-term protective immunity. Yet it is becoming clearer that the phenotypes and functions of T cells are inherent
Antibody and chimeric antigen receptor (CAR) T cell-mediated targeted therapies have improved survival in patients with solid and haematologic malignancies1–9. Adults with T cell leukaemias and lymphomas, collectively called T cell cancers, have short s