A total of 5ml venous blood was collected prior to treatment with LA and we determined the proportion of Tregs CD4+ T cells:CD4+CD25intCD127lowFoxP3+ by immuno-phenotying (IPT), and quantified inflammatory cytokines : IFN-gamma, TNF-alpha and anti-inflammatory cytokine: IL-10, TGFbeta ...
Regulatory T cells and T-cell-derived IL-10 interfere with effective anti-cytomegalovirus immune response. Immunol. Cell Biol. http://dx.doi.org/10.1038... Jost,H Nils,Abel,... 被引量: 0发表: 0年 Nonredundant Roles for B Cell-Derived IL-10 in Immune Counter-Regulation IL-10 plays a...
Impaired interleukin-2 production and regulatory T cell dysfunction is implicated in multiple autoimmune diseases. Here, in two phase lb trials, the authors show that rezpegaldesleukin, a Treg-selective pegylated IL-2, is safe and improves symptoms in patients with atopic dermatitis or psoriasis. ...
Contrasting roles for all-trans retinoic acid in TGF-β–mediated induction of Foxp3 and Il10 genes in developing regulatory T cells Extrathymic induction of regulatory T (T reg) cells is essential to the regulation of effector T cell responses in the periphery. In addition to Foxp3, T r....
III. Further characterisation of the CD4+ suppressor cell and its mechanism of action. J. Exp. Med. 171, 141–157 (1990). Article CAS PubMed Google Scholar Hara, M. et al. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J. Immunol. 166, ...
Tran DQ, Ramsey H and Shevach EM. Induction of FOXP3 expression in naive human CD4+FOXP3- T cells by T cell receptor stimulation is TGF{beta}-dependent but does not confer a regulatory phenotype. Blood 2007; 110:2983–90. Google Scholar Fantini MC, Becker C, Monteleone G, Pallone F...
Objective: To investigate the clinical significance of regulatory T cells(CD4~+CD25~+Treg), interleukin(IL)-10 and interferon-γ(INF-γ) in postoperative follow-up of early cervical cancer. Methods: The expression levels of regulatory T cells, IL-10 and INF-γ in 120 early cervical cancers ...
Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells. Oral antigen preferentially generates a Th2(IL-4/IL-10)- or a Th3(TGF-尾)-type response. Th3-type cells are a unique T-cell subset which ... HL Weiner - 《Microbes & Infection》 被引...
Impact of HepG2 supernatants on T cell subpopulations differentiation, cytokines in supernatants were examed by FACS and ELISA respectively. Anti-IL-10R antibody and JAK1 inhibitor were used to reconfirm the role of tumor-derived IL-10 play in the regulation on iTregs. Hepatocarcinoma cells (HCC...
Intestinal regulatory T (Treg) cells consist of at least three subpopulations: IL-10+RORγt+ microbiota-stimulated peripherally derived Treg (pTreg) cells, RORγt−NRP1− dietary antigen-stimulated pTreg cells and GATA3+ thymus-derived Treg (tTreg) cells. Treg cell subpopulations have comple...