IL-10-producing regulatory B cells (B10 cells) in autoimmune disease. Arthritis Res Ther. 2013; 15 Suppl 1 :S1. doi: 10.1186/ar3907. [ Cross Ref ]Kalampokis I , Yoshizaki A , Tedder TF . 2013 . IL-10-producing regulatory B cells (B10 cells) in autoimmune disease . Arthritis Res...
大鼠缺乏产内生性IL-10的调节性B细胞加重病情,且Th1/Th17的表达增加而在调节性T细胞中减少 Source Division of Medicine, Centre for Rheumatology Research, University College London, London W1T 4JF, United Kingdom. Abstract IL-10-producing B cells, also known asregulatoryB cells (Bregs), play a ke...
Non-specific immune responses to antigens have been demonstrated as being enhanced during chronic hepatitis B virus (HBV) infection. Here, we evaluated the role of interleukin-10 (IL-10)-producing regulatory B-cells (Bregs) in the pathogenesis of HBV-related liver fibrosis (HBV-LF) and assess...
In addition to the detrimental role of B cells in MS, B cells are also essential in disease mitigation15and restriction of inflammation. This is achieved by regulatory B cells (Bregs), a subpopulation of B cells that is functionally characterized by its ability to suppress the immune response....
Here, we first found negative correlations between IL-10+ regulatory B (Breg) cell numbers and Tfh cell responses and disease activity in patients with pSS and mice with experimental Sjögren’s syndrome (ESS). Moreover, we detected high expression of IL-10 receptor on Tfh cells and their...
IL-10-producing regulatory B cells are decreased in patients with atopic dermatitis and are inversely correlated with disease severityThe interaction of programmed death-1 (PD-1) with its ligand, programmed death ligand-1 (PD-L1), has been considered to play a key role in the negative ...
IL-10-producing regulatory B cells restrain the T follicular helper cell response in primary Sjgren's syndrome Increased numbers of T follicular helper(Tfh)cells have been implicated in the development of autoimmune diseases including primary Sjgren's syndrome(pSS),... X Lin,X Wang,F Xiao,.....
A subset of interleukin (IL)-10-producing regulatory B (Breg) cells that suppress T-cell-mediated immunity was recently identified; however, their role in chronic hepatitis B (CHB) remains elusive.To explore the possible role of Breg in the interaction with Th cells and consequent pathogenesis ...
Regulatory B (Breg) cells are essential to the maintenance of peripheral tolerance, but upregulated Breg response may impede the clearance of pathogens and tumor cells. Here, we found that in PBMCs, the frequency of IL-10+ circulating B cells ex vivo and following stimulation was similar ...
IL-10 secretion is the characteristic activity of regulatory B cells in regulating inflammatory disease; therefore, CD19+ and IL-10+ are commonly used as markers for IL-10-producing regulatory B cells (B10)17,18. B10 participates in modulating Th immune response by affecting the secretion of ...