功能：IL-5曾补称为T细胞替代因子（Tcellreplacingfactor，TRF），后来发现人类的IL-5对B细胞没有明显...
2024年9月25日,相关研究以“A type 2 cytokine Fc–IL-4 revitalizes exhaustedCD8+T cells against cancer”为题在线发表在Nature,EPFL唐力教授、浙江大学药学院郭雨刚研究员以及耶鲁大学樊荣教授为论文的共同通讯作者。值得一提的是,...
IL-18 and T cell receptor–mediated stimulation could induce nave CD4T cells to develop into IL-4–producing cells. Thus, caspase-1 and IL-18 may be critical in regulation of IgE production, providing a potential therapeutic target for allergic disorders.Tomohiro Yoshimoto...
通过靶向IL4Rα双重阻断IL-4和IL-13可阻断细胞内信号转导，从而抑制Th2细胞分化、IgE合成和炎性物质...
Interleukin-4 precursor (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Lymphocyte stimulatory factor 1) (B-cell IGG differentiation factor) (B-cell growth factor 1). Protein Family: Belongs to the IL-4/IL-13 family. 售后服务 相关...
IL-4的缺失导致总CD8 T细胞、PD1+CD4+T细胞和DC细胞的增加。在抗PD-1治疗后,Il4敲除肿瘤中的淋巴细胞聚集显示出所有CD8 T细胞亚群的显著富集,包括GZMB+PRF+CTLs。所以,尽管IL-4仅由一小部分卵巢癌细胞产生,但这种IL-4仍可以促...
Expression of the gene encoding IL-4 by T cells is regulated in two steps — the early stages of T-cell differentiation and the later stage of acute gene expression by differentiated TH2 effector cells. During the first stage, the transcription factor GATA3 (GATA-binding protein 3), which ...
期刊：genes to cell（IF:1.3）人星状病毒（HAstV）在全球范围内是导致胃肠炎的主要病原体。尽管如此，由于尚未明确病毒依赖的功能受体，目前对于其易感性的分子控制机制仍不完全了解。日本研究人员通过全基因组CRISPR-Cas9筛选，发现了新生儿Fc受体（FcRn）是HAstV感染的功能性受体。他们的实验结果表明，FcRn的缺失...
Interleukin-4(IL-4)is a pleiotropic cytokine that induces differentiation of naive helper T cells(Th0 cells)to Th2 cells.It is produced by mast cells,activated T cells and bone marrow stromal cells.It has many biological roles,including the stimulation of activated B-cell and T-cell prolifera...